Chronic hand eczema: A prospective analysis of the Swiss CARPE registry focusing on factors associated with clinical and quality of life improvement.

Cazzaniga, Simone; Ballmer-Weber, Barbara K; Gräni, Nora; Spring, Philippe; Bircher, Andreas; Anliker, Mark; Sonntag, Anne-Katharina; Piletta, Pierre; Huber, Caroline; Diepgen, Thomas L; Apfelbacher, Christian; Naldi, Luigi; Borradori, Luca; Simon, Dagmar (2018). Chronic hand eczema: A prospective analysis of the Swiss CARPE registry focusing on factors associated with clinical and quality of life improvement. Contact dermatitis, 79(3), pp. 136-148. Wiley-Blackwell 10.1111/cod.13041

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BACKGROUND Hand eczema (HE) is common and may follow a chronic disease course. So far, prospective studies investigating the risk factors for disease progression as a prerequisite for targeted prevention are scarce. OBJECTIVE To evaluate the overall association of HE-associated factors with clinical and quality of life (QoL) improvement during a follow-up of 2 years. METHODS Data of the prospective patient cohort (N = 199) followed by the Swiss chronic HE (CHE) registry on long-term patient management (CARPE-CH) were analysed by means of both classic regression and semantic map analyses. RESULTS Both severity of HE and QoL significantly improved over the period of 2 years (P < .001). However, 20% of patients had moderate to severe HE after 2 years of follow-up. As factors associated with an unfavourable CHE clinical course and QoL, environmental exposures, male sex, occupational skin disease, job loss or change at baseline, allergic contact dermatitis, a chronic disease course, palmar localization and widespread eczema were identified. CONCLUSIONS Analysis of prospective data from CARPE-CH shows a complex pattern of associations among variables as shown by semantic map and classic statistical analyses. Factors related to occupational exposure had the highest impact on CHE.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Cazzaniga, Simone; Borradori, Luca and Simon, Dagmar

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0105-1873

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Sandra Nyffenegger

Date Deposited:

30 Nov 2018 09:44

Last Modified:

10 Dec 2018 15:20

Publisher DOI:

10.1111/cod.13041

PubMed ID:

29943397

Uncontrolled Keywords:

CARPE chronic hand eczema clinical improvement epidemiology follow-up quality of life semantic map analysis

BORIS DOI:

10.7892/boris.121871

URI:

https://boris.unibe.ch/id/eprint/121871

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