Variation in Endoscopic Activity Assessment and Endoscopy Score Validation in Adults with Eosinophilic Esophagitis.

Schoepfer, Alain M; Hirano, Ikuo; Coslovsky, Michael; Roumet, Marie C; Zwahlen, Marcel; Kuehni, Claudia E; Hafner, David; Alexander, Jeffrey A; Dellon, Evan S; Gonsalves, Nirmala; Leung, John; Bussmann, Christian; Collins, Margaret H; Newbury, Robert O; Smyrk, Thomas C; Woosley, John T; Yang, Guang-Yu; Romero, Yvonne; Katzka, David A; Furuta, Glenn T; ... (2019). Variation in Endoscopic Activity Assessment and Endoscopy Score Validation in Adults with Eosinophilic Esophagitis. Clinical gastroenterology and hepatology, 17(8), 1477-1488.e10. Elsevier 10.1016/j.cgh.2018.11.032

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Eosinophilic esophagitis (EoE) is assessed endoscopically (endoscopic activity), based on grades of edema, rings, exudates, furrows, and strictures (EREFS). We examined variations in endoscopic assessments of severity, developed and validated 3 EREFS-based scoring systems, and assessed responsiveness of these systems using data from a randomized placebo-controlled trial of patients with EoE.


For the development set, 5 gastroenterologists reviewed EREFS findings from 266 adults with EoE and provided endoscopist global assessment scores (EndoGA, scale of 0 to 10); variation (ΔEndoGA) was assessed using linear regression. We evaluated simple scores (features given arbitrary values from 0 to 3) and developed 2 scoring systems (adjusted score range, 0-100). We then fitted our linear regression model with mean EndoGA to data from 146 adults recruited in centers in Switzerland and the United States between April 2011 and December 2012. For the validation set, we collected data from 120 separate adults (recruited in centers in Switzerland and the United States between May 2013 and July 2014), assessing regression coefficient-based scores using Bland-Altman method. We assessed the responsiveness of our scoring systems using data from a randomized trial of patients with EoE given fluticasone (n=16) or placebo (n=8).


The distribution of EndoGA values differed among endoscopists (mean ΔEndoGA, 2.6±1.8; range 0-6.6). We developed 2 regression-based scoring systems to assess overall and proximal and distal esophageal findings; variation in endoscopic features accounted for more than 90% of the mean EndoGA variation. In the validation group, differences between mean EndoGA and regression-based scores were small (ranging from -4.70 to 2.03), indicating good agreement. In analyses of data from the randomized trial, the baseline to end of study change in patients given fluticasone was a reduction of 24.3 in simple score (reduction of 4.6 in patients given placebo, P=.052); a reduction of 23.5 in regression-based overall score (reduction of 6.56 in patients given placebo, P=.12), and a reduction of 23.8 (reduction of 8.44 in patients given placebo, P=.11).


Assessments of endoscopic activity in patients with EoE vary among endoscopists. In an analysis of data from a randomized controlled trial, we found that newly developed scoring systems are no better than simple scoring system in detecting changes in endoscopic activity. These results support the use of a simple scoring system in evaluation of endoscopic activity in patients with EoE. no: NCT00939263 and NCT 01386112.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
04 Faculty of Medicine > Pre-clinic Human Medicine > Department of Clinical Research (DCR)

UniBE Contributor:

Coslovsky, Michael, Roumet, Marie Camille, Zwahlen, Marcel, Kühni, Claudia, Safroneeva, Ekaterina


600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services








Tanya Karrer

Date Deposited:

30 Nov 2018 11:13

Last Modified:

20 Feb 2024 14:16

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

esophagus index instrument variability in endoscopic assessment




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