Association of Hidradenitis Suppurativa With T Helper 1/T Helper 17 Phenotypes: A Semantic Map Analysis.

Thomi, Rahel; Cazzaniga, Simone; Jafari, Morteza; Schlapbach, Christoph; Hunger, Robert (2018). Association of Hidradenitis Suppurativa With T Helper 1/T Helper 17 Phenotypes: A Semantic Map Analysis. JAMA dermatology, 154(5), pp. 592-595. American Medical Association 10.1001/jamadermatol.2018.0141

Text jamadermatology_Thomi_2018_br_180002.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (160kB)

Importance

In spite of progress in understanding the mechanisms underlying hidradenitis suppurativa (HS) as an inflammatory skin disease, there is still a demand for an overview on immunopathogenesis of HS.

Objective

To demonstrate the importance of the type 1/type 17 immune response in lesional HS skin by drawing a semantic connectivity map.

Design, Setting, and Participants

Single-center case series of 24 patients with HS. Association of HS with T helper 1/T helper 17 (TH1/TH17) phenotype was assessed using semantic map analysis.

Main Outcomes and Measures

Association of HS with TH1/TH17 phenotype.

Results

The analysis was performed on 24 lesional HS biopsy samples from untreated patients with HS (16 [67%] female; median age, 36.5 years [range, 21-51 years]) with a mean (SD) Hurley stage of 2.29 (0.62) and 9 punch biopsy samples from healthy controls (6 [67%] female; median age, 43 years [range, 23-66 years]). The map shows a clustering of all TH1/TH17-associated cytokines (interleukin 17 [IL-17], interferon γ, IL-12, IL-23, IL-32, IL-1β, tumor necrosis factor) around overall lesional inflammation. Tumor necrosis factor, IL-12, and IL-17 are even directly connected via interferon γ. In contrast, IL-13, a TH2-associated cytokine, was inversely correlated with the presence of TH1/TH17-associated cytokines, further highlighting the importance of the TH1/TH17 cytokines in HS pathogenesis.

Conclusions and Relevance

These findings suggest that HS may be a TH1/TH17-driven inflammatory skin disease.

Interest & Impact

Downloads

1 since deposited on 07 Dec 2018
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item