Association of Hidradenitis Suppurativa With T Helper 1/T Helper 17 Phenotypes: A Semantic Map Analysis.

Thomi, Rahel; Cazzaniga, Simone; Jafari, Morteza; Schlapbach, Christoph; Hunger, Robert (2018). Association of Hidradenitis Suppurativa With T Helper 1/T Helper 17 Phenotypes: A Semantic Map Analysis. JAMA dermatology, 154(5), pp. 592-595. American Medical Association 10.1001/jamadermatol.2018.0141

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Importance In spite of progress in understanding the mechanisms underlying hidradenitis suppurativa (HS) as an inflammatory skin disease, there is still a demand for an overview on immunopathogenesis of HS. Objective To demonstrate the importance of the type 1/type 17 immune response in lesional HS skin by drawing a semantic connectivity map. Design, Setting, and Participants Single-center case series of 24 patients with HS. Association of HS with T helper 1/T helper 17 (TH1/TH17) phenotype was assessed using semantic map analysis. Main Outcomes and Measures Association of HS with TH1/TH17 phenotype. Results The analysis was performed on 24 lesional HS biopsy samples from untreated patients with HS (16 [67%] female; median age, 36.5 years [range, 21-51 years]) with a mean (SD) Hurley stage of 2.29 (0.62) and 9 punch biopsy samples from healthy controls (6 [67%] female; median age, 43 years [range, 23-66 years]). The map shows a clustering of all TH1/TH17-associated cytokines (interleukin 17 [IL-17], interferon γ, IL-12, IL-23, IL-32, IL-1β, tumor necrosis factor) around overall lesional inflammation. Tumor necrosis factor, IL-12, and IL-17 are even directly connected via interferon γ. In contrast, IL-13, a TH2-associated cytokine, was inversely correlated with the presence of TH1/TH17-associated cytokines, further highlighting the importance of the TH1/TH17 cytokines in HS pathogenesis. Conclusions and Relevance These findings suggest that HS may be a TH1/TH17-driven inflammatory skin disease.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Thomi, Rahel; Cazzaniga, Simone; Jafari, Morteza; Schlapbach, Christoph and Hunger, Robert

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2168-6084

Publisher:

American Medical Association

Language:

English

Submitter:

Sandra Nyffenegger

Date Deposited:

07 Dec 2018 09:32

Last Modified:

07 Dec 2018 09:32

Publisher DOI:

10.1001/jamadermatol.2018.0141

PubMed ID:

29617527

BORIS DOI:

10.7892/boris.121888

URI:

https://boris.unibe.ch/id/eprint/121888

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