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[ (the) -334.8 (total) -333.8 (SPRINT) -332.8 (population) -338 (and) -330.8 (after) -334.1 (1\0563\054) -338.3 (1\0563\054) -332 (1\0561\054) -332 (1\0568\054) ] TJ
0 -1.2266 TD
[ (2\0561\054) -338.3 (1\0568\054) -332 (and) -330.8 (3\0564) -334.8 (years) -332.5 (among) -336.7 (participants) -337.5 (with) -329 (prevalent) ] TJ
0 -1.2203 TD
[ (chronic) -338.5 (kidney) -335.4 (disease\054) -333.5 (prevalent) -332.8 (cardiovascular) -338.7 (disease\054) ] TJ
T*
[ (women\054) -338.9 (black) -331.1 (individuals\054) -339.8 (participants) -331.1 (less) -339.3 (than) -332.9 (75) -331.3 (years\054) ] TJ
0 -1.2266 TD
[ (those) -333.5 (with) -335.3 (baseline) -337 (SBP) -332.2 (more) -336.4 (than) -332.9 (132) -158.6 (mmHg\054) -331.4 (and) ] TJ
0 -1.2203 TD
[ (individuals) -336.3 (who) -334.3 (suffered) -337.2 (SAEs) -332.7 (during) -332.8 (follow\055up\054) ] TJ
T*
(respectively\056) Tj
/F4 1 Tf
0 -1.5554 TD
(Conclusion\072) Tj
/F6 1 Tf
5.7602 0 TD
[ (The) -332.2 (initial) -341.6 (beneficial) -331 (impact) -335.2 (of) -335.3 (intensive) ] TJ
-5.7602 -1.2266 TD
[ (hypertension) -334.5 (treatment) -335.3 (might) -338.2 (be) -332.7 (offset) -333.3 (by) -335.1 (cumulative) -331.7 (SBP) ] TJ
0 -1.2203 TD
[ (and) -337.1 (development) -334.7 (of) -329 (SAEs) -339 (during) -332.8 (follow\055up\056) ] TJ
/F4 1 Tf
0 -1.5554 TD
(Keywords\072) Tj
/F6 1 Tf
5.3365 0 TD
[ (adverse) -330 (effects\054) -340.2 (cumulative) -331.7 (joint) -340 (model\054) ] TJ
-5.3365 -1.2203 TD
[ (intensive) -335.2 (treatment\054) -338.8 (randomized) -335.3 (controlled) -333.3 (trial\054) -336.3 (SBP\054) ] TJ
T*
[ (treatment) -335.3 (efficacy) ] TJ
/F4 1 Tf
0 -1.8906 TD
(Abbreviations\072) Tj
/F6 1 Tf
7.2271 0 TD
[ (cJM\054) -336.5 (cumulative) -338 (joint) -333.6 (model\073) -332.8 (CKD\054) -340 (chronic) ] TJ
-7.2271 -1.2266 TD
[ (kidney) -335.4 (disease\073) -333.5 (CVD\054) -340 (cardiovascular) -332.3 (disease\073) -339.8 (LMM\054) -334.6 (linear) ] TJ
0 -1.2203 TD
[ (mixed) -339.5 (effect) -329.7 (model\073) -339.1 (SAEs\054) -329.9 (serious) -337.5 (adverse) -336.4 (events\073) -334.1 (SPRINT\054) ] TJ
T*
[ (Systolic) -339.5 (Blood) -330.7 (Pressure) -337.2 (Intervention) -334.8 (Trial) ] TJ
/F8 1 Tf
11.9551 0 0 11.9551 337.3795 563.0172 Tm
0.0228 Tc
[ (IN) 10.3 (T) 15.3 (R) 81.5 (O) 33.9 (D) 53 (U) 62.5 (C) 22.8 (T) 7.7 (I) 42.7 (O) 43.4 (N) ] TJ
/F9 1 Tf
42.8394 0 0 42.8394 337.3795 523.8991 Tm
0 Tc
(H) Tj
9.9626 0 0 9.9626 374.0598 545.8393 Tm
-0.0151 Tc
[ (i) -15.1 (g) -15.1 (h) -403 (b) -15.1 (l) 10.2 (ood) -352.2 (pressure) -351.6 (\050B) -15.1 (P) 9.7 (\051) -351 (is) -354.2 (a) -355.5 (m) -1.2 (ajor) -355 (modi) -15.1 (f) 12 (i) 0.2 (ab) -15.1 (l) 10.2 (e) -351.6 (risk) ] TJ
0 -1.0983 TD
0 Tc
[ (f) 17.5 (a) 12.4 (c) 14.1 (t) 19.2 (or) -176.2 (f) 17.5 (o) 15.7 (r) -186.2 (c) 14.1 (a) 12.4 (r) 18.6 (di) 25.3 (o) 15.7 (v) 16.3 (a) 12.4 (s) 19.4 (c) 14.1 (u) 0 (l) 25.3 (a) 18.1 (r) -186.2 (d) 15.7 (i) 15.3 (s) 13.7 (ea) 28.7 (s) 13.7 (e) -182.9 (\050) 11.2 (C) 16.1 (V) 14.7 (D) 0 (\051) -171.7 (\133) 17.1 (1\054) 25.9 (2) 16.3 (\135) 17.1 (\056) -189.6 (I) 14.7 (n) -183.5 (a) 12.4 (d) 15.7 (d) 15.7 (i) 15.3 (\055) ] TJ
0 -1.104 TD
-0.0154 Tc
[ (tion) -176.1 (to) -176.1 (higher) -178.9 (base) -15.4 (l) 10.5 (i) -0.1 (ne) -169.8 (B) -15.4 (P) 9.4 (\054) -170.8 (v) 0.9 (isit\055to\055visit) -172.6 (v) -15.4 (a) 13.3 (r) -2.4 (iab) -15.4 (i) 9.9 (lity) -169.8 (a) -3 (nd) ] TJ
-3.6818 -1.0983 TD
-0.0151 Tc
[ (cumulative) -192.3 (exposure) -192.3 (to) -192.9 (BP) -192.9 (have) -192.3 (been) -192.9 (linked) -192.9 (t) -1.6 (o) -187.2 (h) -15.1 (i) 10.2 (g) 4.1 (h) -15.1 (e) 11.2 (r) -189.9 (r) -2.1 (isk) -191.1 (f) 2.4 (o) -15.1 (r) ] TJ
T*
-0.0154 Tc
[ (CVD) -357.6 (a) -3 (nd) -358.2 (kid) -15.4 (n) 10.3 (ey) -357.6 (dysfunction) -358.2 (\1333) -84.5 (\226) -84.5 (5) 0.9 (\135\056) -358.6 (Intrain) -15.4 (d) 10.3 (ividu) -15.4 (a) 12.7 (l) -358.6 (B) -0.7 (P) -358.2 (f) 2.1 (luc\055) ] TJ
0 -1.104 TD
-0.015 Tc
[ (tuation) -15 (s) -201.8 (are) -209.2 (n) 0.7 (o) -15 (t) -196.3 (random) -211.6 (and) -215.5 (t) 4.2 (en) -15 (d) -199.8 (t) -1.5 (o) -209.8 (p) -1.1 (ersist) -206.3 (within) -209.8 (i) -15 (n) 10.3 (divid) -15 (u) 10.7 (als) ] TJ
0 -1.0983 TD
-0.0154 Tc
[ (\1336) -15.4 (\054) 10.5 (7) 0.9 (\135\056) -495.2 (Th) -15.4 (e) 10.9 (r) -2.5 (efore\054) -500.9 (the) -499.9 (c) -1.3 (onve) -15.4 (n) 10.9 (tional) -495.2 (a) 2.7 (pproach) -494.8 (o) 0.3 (f) -498.7 (c) -1.3 (orre) -15.4 (l) 10.5 (a) 2.7 (ting) ] TJ
T*
-0.0146 Tc
[ (baseline) -311.3 (B) 0.1 (P) -311.9 (w) -1.8 (ith) -311.9 (outcomes) -313.9 (o) 1.1 (f) -310.1 (i) 0.7 (n) -14.6 (t) 14.7 (e) -14.6 (r) 14.7 (e) -14.6 (s) 15.4 (t) -314 (i) 0.7 (n) -311.9 (c) -0.5 (linical) -306.6 (trials) -308.2 (might) ] TJ
0 -1.104 TD
-0.0172 Tc
[ (lea) -4.8 (d) -303.1 (to) -303.1 (b) -17.2 (i) 8.1 (as) -3.5 (ed) -303.1 (e) -17.2 (s) 12.8 (t) -3.7 (i) -1.9 (m) -3.3 (a) -4.8 (te) -17.2 (s) -288.8 (r) -4.3 (eg) -3.7 (a) -4.8 (r) 1.4 (d) -17.2 (i) 8.1 (ng) -305.3 (tr) -4.3 (ea) -4.8 (tm) -17.2 (e) 7.4 (n) -1.5 (t) -299.6 (e) -17.2 (f) 10.9 (f) 0.3 (ic) -3.1 (a) -4.8 (c) -3.1 (y\056) ] TJ
1.2007 -1.0983 TD
0 Tc
[ (Tre) 14.8 (atm) 11.4 (ent) -421.1 (of) -427.7 (hyp) 11.8 (er) 12.2 (ten) 11.4 (si) 12 (on) -429.5 (and) -428.5 (low) 15.3 (er) 12.2 (ing) -427.8 (BP) -430.5 (ha) 11 (s) -435.8 (bee) 14.2 (n) ] TJ
-1.2007 -1.0983 TD
[ (con) 11.4 (si) 12 (ste) 15.1 (ntl) 16.1 (y) -319.4 (ass) 17.1 (oci) 11 (ate) 13.8 (d) -314.4 (w) 0 (i) 11 (t) 0 (h) -312.2 (ben) 13.6 (efi) 14.9 (ci) 12.4 (al) -313.7 (cl) 12.4 (ini) 12.2 (cal) -305.3 (out) 10.8 (co) 12.8 (mes) -308.8 (in) ] TJ
T*
[ (obs) 11 (er) 12.2 (va) 11.6 (tio) 10.4 (na) 11 (l) -155.4 (stu) 14.5 (di) 14 (es) -152.1 (an) 11 (d) -155 (ran) 12.6 (dom) 11.2 (iz) 12.4 (ed) -150.1 (cli) 16.3 (nic) 11 (al) -148.7 (tri) 13.3 (als) -140.7 (\1338\135) 16.3 (\056) -155.4 (A) 0 (s) -153.6 (t) 0 (h) 12.2 (e) ] TJ
0 -1.104 TD
[ (epi) 17.1 (dem) 11.8 (iol) 12.2 (og) 12.2 (ica) 13.4 (l) -286.3 (ass) 17.1 (oci) 11 (ati) 18.5 (ons) -279.2 (of) -279.8 (BP) -276.8 (wi) 11 (th) -283.7 (car) 16.7 (dio) 12.6 (va) 11.6 (sc) 10.8 (ular) -273.7 (ri) 11.2 (sk) ] TJ
0 -1.0983 TD
[ (do) -275.9 (not) -268 (ind) 12.6 (ica) 13.4 (te) -271.7 (a) -283.5 (c) 0 (l) 12.4 (e) 0 (a) 11.6 (r) -283 (low) 15.3 (er) -278 (bou) 13 (nd) -275.9 (th) 12.2 (re) 12.2 (sho) 11 (ld) -276.3 (\1339\135) 16.3 (\054) -280.6 (low) 15.3 (eri) 16.1 (ng) ] TJ
T*
[ (th) 12.2 (e) -291 (B) 0 (P) -288.2 (t) 0 (o) -283.7 (the) -278.8 (lowe) 14.6 (st) -285.7 (to) 12.2 (ler) 16.1 (abl) 14.9 (e) -291 (lev) 13.8 (els) -279 (is) -283.9 (dee) 14.2 (med) -284.1 (to) -283.7 (yie) 13.8 (ld) -287.7 (th) 12.2 (e) ] TJ
0 -1.104 TD
[ (gre) 14.4 (ate) 13.8 (st) -262.9 (cl) 12.4 (ini) 12.2 (cal) -259.8 (ben) 13.6 (efi) 14.9 (t) -265.3 (\13310) 15.5 (\05411) 13.8 (\135\056) -263.5 (How) 10.7 (eve) 14.8 (r\054) -262 (int) 16.1 (ens) 11.6 (ive) -259.4 (BP) -265.5 (low) 15.3 (\055) ] TJ
0 -1.0983 TD
[ (er) 12.2 (ing) -171.7 (ha) 11 (s) -174.1 (adve) 15.2 (rse) -167.6 (eff) 17.1 (ect) 15.5 (s) -174.1 (tha) 13.2 (t) -179.9 (c) 0 (o) 12.8 (uld) -169.5 (im) 12.2 (pac) 12 (t) -174.2 (the) -170.7 (eff) 17.1 (ic) 12.4 (acy) -167.7 (of) -171.7 (thi) 16.1 (s) ] TJ
T*
[ (int) 16.1 (erv) 11.4 (ent) 17.1 (ion) -345.9 (\13312) 15.5 (\135\056) -348.9 (Re) 13.2 (cen) 12 (t) -350.7 (evi) 13.8 (den) 13.6 (ce) -345.1 (fro) 12 (m) -355.9 (t) 0 (h) 12.2 (e) -353.6 (Sy) 11.6 (sto) 14.5 (lic) -342.2 (Blo) 11.6 (od) ] TJ
0 -1.104 TD
[ (Pr) 11.6 (essu) 14 (re) -289.4 (In) 13.4 (ter) 14.4 (ven) 14.2 (ti) 11.8 (on) -292.9 (Tri) 13.8 (al) -285.3 (\050SP) 10.8 (RI) 11.6 (NT\051) -285.1 (sho) 11 (we) 12 (d) -297.3 (t) 0 (h) 12.2 (a) 0 (t) -287 (int) 10.4 (ens) 17.3 (ive) ] TJ
0 -1.0983 TD
[ (low) 15.4 (eri) 10.4 (ng) -306.5 (of) -302.6 (BP) -311 (si) 12 (gni) 16.1 (fic) 12.8 (an) 11 (tly) -302 (red) 10.8 (uc) 12.8 (ed) -309.4 (maj) 16.7 (or) -307.1 (vas) 14 (cul) 11 (ar) -304.7 (eve) 14.8 (nt) 12.2 (s) ] TJ
T*
[ (\13313) 15.5 (\135\056) -149.7 (Alt) 15.1 (hou) 13 (gh) -152.8 (the) -147.9 (fr) 13.4 (equ) 13.6 (enc) 12 (y) -154.4 (o) 0 (f) -148.9 (seri) 18.5 (ous) -148.3 (ad) 11 (ver) 11.4 (se) -152.1 (eve) 14.8 (nt) 12.2 (s) -157 (\050) 0 (S) 12.2 (AEs) 10 (\051) ] TJ
0 -1.104 TD
[ (was) -166 (equ) 13.6 (al) -165.8 (in) -168.2 (bot) 16.5 (h) -172.1 (con) 11.4 (ven) 14.2 (ti) 11.8 (ona) 15.4 (l) -172.5 (and) -166.7 (int) 16.1 (ens) 11.6 (iv) 14.5 (e) -177.2 (tre) 20 (atm) 11.4 (ent) -165 (ar) 14 (ms) ] TJ
ET
/EmbeddedDocument /MC1 BDC
/Document /MC2 BDC
q
1 i
109.216 757.966 -38.939 -14.988 re
70.277 757.966 m
W
n
q
39.246 0 0 15.144 70.248 742.908 cm
/Im1 Do
Q
Q
q
1 i
109.512 758.341 -39.61 -15.733 re
69.902 758.341 m
W
n
0 0 0 0.8 K
0 J
0 j
0.75 w
10 M
[ ] 0 d
/GS2 gs
109.137 742.983 -38.86 14.983 re
S
Q
/GS2 gs
1 i
q
1 0 0 1 76.266 750.373 cm
0 0 m
0 -0.795 0.231 -1.421 0.695 -1.878 c
1.159 -2.335 1.741 -2.563 2.441 -2.563 c
3.154 -2.563 3.741 -2.333 4.201 -1.871 c
4.662 -1.409 4.892 -0.754 4.892 0.095 c
4.892 0.631 4.794 1.1 4.597 1.5 c
4.4 1.9 4.112 2.21 3.732 2.431 c
3.354 2.651 2.928 2.762 2.456 2.762 c
1.785 2.762 1.208 2.549 0.725 2.125 c
0.241 1.7 0 0.992 0 0 c
h
-0.977 0.014 m
-0.977 1.107 -0.658 1.965 -0.02 2.584 c
0.618 3.203 1.441 3.513 2.451 3.513 c
3.111 3.513 3.707 3.367 4.238 3.076 c
4.768 2.785 5.173 2.38 5.451 1.859 c
5.729 1.34 5.869 0.749 5.869 0.09 c
5.869 -0.579 5.723 -1.177 5.43 -1.705 c
5.137 -2.232 4.722 -2.632 4.184 -2.903 c
3.647 -3.175 3.067 -3.31 2.446 -3.31 c
1.772 -3.31 1.17 -3.16 0.64 -2.86 c
0.108 -2.56 -0.293 -2.151 -0.566 -1.633 c
-0.84 -1.114 -0.977 -0.565 -0.977 0.014 c
f
Q
q
1 0 0 1 84.903 750.634 cm
0 0 m
1.851 0 l
2.463 0 2.897 0.105 3.154 0.314 c
3.412 0.524 3.54 0.82 3.54 1.201 c
3.54 1.477 3.465 1.713 3.313 1.909 c
3.162 2.105 2.963 2.235 2.715 2.298 c
2.556 2.337 2.261 2.356 1.831 2.356 c
0 2.356 l
0 0 l
h
-0.947 -3.458 m
-0.947 3.135 l
1.753 3.135 l
2.228 3.135 2.592 3.113 2.842 3.071 c
3.193 3.018 3.488 2.915 3.726 2.764 c
3.964 2.612 4.154 2.4 4.3 2.127 c
4.444 1.854 4.517 1.555 4.517 1.228 c
4.517 0.667 4.323 0.192 3.935 -0.195 c
3.549 -0.584 2.849 -0.778 1.836 -0.778 c
0 -0.778 l
0 -3.458 l
-0.947 -3.458 l
f
Q
q
1 0 0 1 91.246 747.176 cm
0 0 m
0 6.593 l
5.176 6.593 l
5.176 5.814 l
0.947 5.814 l
0.947 3.795 l
4.907 3.795 l
4.907 3.021 l
0.947 3.021 l
0.947 0.777 l
5.342 0.777 l
5.342 0 l
0 0 l
f
Q
q
1 0 0 1 98.486 747.176 cm
0 0 m
0 6.593 l
0.972 6.593 l
4.731 1.416 l
4.731 6.593 l
5.64 6.593 l
5.64 0 l
4.668 0 l
0.908 5.181 l
0.908 0 l
0 0 l
f
Q
EMC
EMC
/GS1 gs
337.379 299.792 249.562 0.45358 re
f
BT
/F6 1 Tf
6.9738 0 0 6.9738 337.3795 287.8299 Tm
0.0001 Tc
[ (Journal) -341.5 (of) -334.3 (Hypertension) -343.9 (2018\054) -339.7 (36\072000) -88.5 (\226) -77.1 (0) 0 (0) -9.6 (0) ] TJ
5.2302 0 0 4.6485 337.3795 280.0063 Tm
0 Tc
(a) Tj
6.9738 0 0 6.9738 339.9873 276.8881 Tm
0.0001 Tc
[ (Depart) -9.7 (ment) -285.6 (of) -293.6 (Epidemiol) -10.6 (ogy\054) -289.5 (E) 0 (rasm) -9.5 (us) -290.4 (MC) -375.5 (\226) -369.8 (Univers) -12.2 (ity) -286.3 (Medica) -11.2 (l) -285.9 (Cente) -9.5 (r) -284.7 (Rotterda) -11 (m) 0 (\054) ] TJ
-0.374 -1.1462 TD
0 Tc
[ (Rotterdam\054) -360.2 (T) 0 (he) -350.2 (Netherlands\054) ] TJ
5.2302 0 0 4.6485 426.3873 272.0125 Tm
(b) Tj
6.9738 0 0 6.9738 429.2786 268.8945 Tm
[ (Electro) -10.8 (cardiography) -355.3 (Resea) -9.8 (rch) -350.7 (Group\054) -352.9 (Depar) -9.5 (tment) -351 (of) ] TJ
-13.1778 -1.1381 TD
[ (Basic) -312.3 (Scien) -10.3 (ces\054) -313.5 (School) -316.7 (of) -310 (Medicine\054) -317.8 (Univers) -12.3 (idad) -307.8 (Industri) -10.9 (al) -306.3 (d) -8.9 (e) -304.8 (Sant) -9 (ander\054) -314 (U) -0.1 (IS\054) -310.3 (B) 0 (ucar\055) ] TJ
0 -1.1462 TD
[ (amanga\054) -208.2 (San) -8.8 (tander\054) -208.6 (Colombia\054) ] TJ
5.2302 0 0 4.6485 430.3558 256.0818 Tm
(c) Tj
6.9738 0 0 6.9738 432.6802 252.9638 Tm
0.0001 Tc
[ (Depa) -9.2 (rtment) -204.8 (o) 0 (f) -204.2 (P) 0.1 (ed) -8.6 (iatrics\054) -211.2 (Obstetrics) -209.8 (a) 0.1 (nd) -208.6 (Gyne) -10.2 (cology) ] TJ
-13.6656 -1.1381 TD
0 Tc
[ (and) -363.2 (Preventive) -368.4 (Medicine) -13.5 (\054) -361.2 (Universitat) -367.9 (Auto) ] TJ
17.7709 0 TD
0.0001 Tc
[ (\140) -164 (noma) -9.7 (\054) -361.1 (B) 0 (arcelona\054) -369 (Spain\054) ] TJ
5.2302 0 0 4.6485 539.7164 248.0882 Tm
0 Tc
(d) Tj
6.9738 0 0 6.9738 542.6077 245.0267 Tm
0.0001 Tc
[ (Department) -368.5 (o) 0.1 (f) ] TJ
-29.4285 -1.1462 TD
[ (Cardiolog) -10.7 (y) 0.1 (\054) -418.1 (Erasmus) -421.8 (MC) -505.6 (\226) -499.8 (University) -428.6 (Medical) -419.1 (C) 0 (ente) -9.5 (r) -414.8 (Rotterdam\054) -425.2 (Rotterdam\054) -425.2 (T) 0.1 (he) ] TJ
0 -1.1381 TD
0 Tc
[ (Netherlands) -13.8 (\054) ] TJ
5.2302 0 0 4.6485 377.4046 232.1575 Tm
(e) Tj
6.9738 0 0 6.9738 380.0125 229.096 Tm
[ (Institute) -364 (of) -358.7 (Social) -361.3 (and) -355.1 (Preventive) -360.3 (Medicine) -13.5 (\054) -353.1 (ISPM\054) -363.5 (U) -0.1 (niversity) -363.7 (of) -358.7 (Bern\054) ] TJ
-6.1133 -1.1462 TD
[ (Bern\054) -253.1 (S) 0 (witzerland) -252.1 (and) ] TJ
5.2302 0 0 4.6485 403.7101 224.2204 Tm
(f) Tj
6.9738 0 0 6.9738 405.4676 221.1024 Tm
[ (Department) -254.8 (o) -0.1 (f) -244.9 (B) -0.1 (iostatist) -11.5 (ics\054) -246 (Erasmus) -251.2 (MC) -334.9 (\226) -329.2 (U) -0.1 (niversity) -258 (Medical) ] TJ
-9.7634 -1.1462 TD
0.0001 Tc
[ (Center) -334.9 (Rot) -9.8 (terdam\054) -334 (Rotterda) -11 (m) 0 (\054) -332.9 (T) 0.1 (he) -333.8 (Nethe) -9.5 (rlands) ] TJ
0 -1.569 TD
[ (Corresponde) -9.8 (nce) -297.4 (t) 0.1 (o) -293.6 (M) 0 (aryam) -298.1 (Kavousi\054) -295.8 (MD\054) -297.7 (PhD\054) -293.2 (FESC\054) -296.5 (Departme) -9.8 (n) 0 (t) -293.6 (o) 0 (f) -285.5 (E) 0.1 (pide) -10.9 (miology\054) ] TJ
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