Mitochondrial protein import in trypanosomatids: Variations on a theme or fundamentally different?

Schneider, André (2018). Mitochondrial protein import in trypanosomatids: Variations on a theme or fundamentally different? PLoS pathogens, 14(11), e1007351. Public Library of Science 10.1371/journal.ppat.1007351

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Mitochondria perform many important functions. Their origin can be traced back to an endosymbotic event between an archaeal host cell and an α-proteobacteria approximately 2 billion years ago [1]. Subsequently, the endosymbiont was converted into an organelle, which learned to import cytosolic proteins, a feat present-day endosymbiontic bacteria are not capable of. Today, the large majority of mitochondrial proteins are encoded in the nucleus, synthesized in the cytosol, and finally imported across the outer and/or the inner mitochondrial membranes. Protein import was one of the first—if not the first—mitochondria-specific trait to evolve. Because mitochondria are monophyletic, the expectation was that the machineries that mediate mitochondrial protein import would be largely conserved. Work in trypanosomes and other organisms in recent years has shown that this is not the case [2, 3]. It is the aim of this review to summarize where we find major deviations in the trypanosomal mitochondrial protein import machineries when compared to the best-studied system, that of the yeast Saccharomyces cerevisiae.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Schneider, André

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

1553-7366

Publisher:

Public Library of Science

Language:

English

Submitter:

Christina Schüpbach

Date Deposited:

07 Dec 2018 13:49

Last Modified:

23 Oct 2019 07:18

Publisher DOI:

10.1371/journal.ppat.1007351

BORIS DOI:

10.7892/boris.122009

URI:

https://boris.unibe.ch/id/eprint/122009

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