Observer-rated retardation but not agitation corresponds to objective motor measures in depression.

van Diermen, Linda; Walther, Sebastian; Cools, Olivia; Fransen, Erik; Birkenhäger, Tom K; Sabbe, Bernard C G; Schrijvers, Didier (2018). Observer-rated retardation but not agitation corresponds to objective motor measures in depression. Acta neuropsychiatrica, 30(6), pp. 359-364. Cambridge University Press 10.1017/neu.2018.21

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OBJECTIVE To explore the correlations between observer ratings and instrumental parameters across domains of psychomotor functioning in depression. METHOD In total, 73 patients with major depressive disorder underwent extensive psychomotor and clinical testing. Psychomotor functioning was assessed with (i) an observer-rated scale (the CORE measure) and also objectively with (ii) 24-h actigraphy, and (iii) a fine motor drawing task. RESULTS Observer ratings of retardation correlated with instrumental assessments of fine and gross motor functioning. In contrast, observer ratings of agitation did not correlate with observer ratings of retardation or with the instrumental measures. These associations were partly influenced by age and, to a lesser extent, by depression severity. CONCLUSION Psychomotor disturbance is a complex concept with different manifestations in depressed patients. Although observer ratings of retardation correspond well with instrumental measures of the motor domains, objective measurement of agitation and other aspects of psychomotor disturbance require further research.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center

UniBE Contributor:

Walther, Sebastian


600 Technology > 610 Medicine & health




Cambridge University Press




Sebastian Walther

Date Deposited:

10 Dec 2018 16:12

Last Modified:

23 Dec 2018 01:34

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

depression neuropsychology psychiatric disorders


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