Approaches to define the viral genetic basis of classical swine fever virus virulence.

Leifer, Immanuel; Ruggli, Nicolas; Blome, Sandra (2013). Approaches to define the viral genetic basis of classical swine fever virus virulence. Virology, 438(2), pp. 51-55. Academic Press 10.1016/j.virol.2013.01.013

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Classical swine fever (CSF), a highly contagious disease of pigs caused by the classical swine fever virus (CSFV), can lead to important economic losses in the pig industry. Numerous CSFV isolates with various degrees of virulence have been isolated worldwide, ranging from low virulent strains that do not result in any apparent clinical signs to highly virulent strains that cause a severe peracute hemorrhagic fever with nearly 100% mortality. Knowledge of the molecular determinants of CSFV virulence is an important issue for effective disease control and development of safe and effective marker vaccines. In this review, the latest studies in the field of CSFV virulence are discussed. The topic of virulence is addressed from different angles; nonconventional approaches like codon pair usage and quasispecies are considered. Future research approaches in the field of CSFV virulence are proposed.

Item Type:

Journal Article (Review Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Ruggli, Nicolas

Subjects:

600 Technology > 630 Agriculture

ISSN:

0042-6822

Publisher:

Academic Press

Language:

English

Submitter:

Monika Mumenthaler

Date Deposited:

12 Dec 2018 14:57

Last Modified:

12 Dec 2018 17:11

Publisher DOI:

10.1016/j.virol.2013.01.013

PubMed ID:

23415391

BORIS DOI:

10.7892/boris.122115

URI:

https://boris.unibe.ch/id/eprint/122115

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