Short- and long-term effects of two emollients on itching and skin restoration in xerotic eczema.

Simon, Dagmar; Nobbe, Stephan; Nägeli, Mirjam; Barysch, Marjam; Kunz, Michael; Borelli, Siegfried; Hasan-Ali, Omar; Wildi, Eckhart; Gasser, Urs Erwin (2018). Short- and long-term effects of two emollients on itching and skin restoration in xerotic eczema. Dermatologic therapy, 31(6), e12692. Wiley-Blackwell 10.1111/dth.12692

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Pruritus is associated with various skin diseases, dry skin, and with it an impaired skin barrier function. The study objective was to investigate short-term and long-term effects of two emollients on symptoms and skin barrier functions in xerotic eczema. Randomized, double-blind, study enrolling females/males, with bilateral itching. Two emollients, containing lactic acid and refined almond oil with/without polidocanol were administered on left versus right body sides. Itching severity, skin moisture, lipid content, and pH were assessed on Day 1, within 30-120 min after first administration, and on Days 7 and 14, and compared with baseline assessments. Severity of itching decreased 30 min after first administration of both emollients compared with baseline (p < .0001) and reached a maximum reduction of 63% (p < .0001) and 69% (p < .0001) on Day 14. Skin moisture and lipid content increased after first application, and further ameliorated within 14 days of treatment (p < .0001). Both emollients were tolerated well, and only a few adverse events were reported. This study confirmed the clinical efficacy of the two study emollients to substantially reduce itching already after first administration, and restore skin barrier integrity and thus should be considered as therapeutic approach for xerotic eczema.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Simon, Dagmar

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1396-0296

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Sandra Nyffenegger

Date Deposited:

28 Dec 2018 15:25

Last Modified:

28 Dec 2018 15:25

Publisher DOI:

10.1111/dth.12692

PubMed ID:

30246910

Uncontrolled Keywords:

almond oil emollients itching lactic acid skin restoration xerotic eczema

BORIS DOI:

10.7892/boris.122269

URI:

https://boris.unibe.ch/id/eprint/122269

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