D-lactic Acidosis: Successful Suppression of D-lactate-Producing Lactobacillus by Probiotics.

Yilmaz, Bahtiyar; Schibli, Susanne; Macpherson, Andrew; Sokollik, Christiane (2018). D-lactic Acidosis: Successful Suppression of D-lactate-Producing Lactobacillus by Probiotics. Pediatrics, 142(3) American Academy of Pediatrics 10.1542/peds.2018-0337

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Intestinal microbiota composition in children with short bowel syndrome (SBS) is an important factor influencing the clinical outcome. An increase of D-lactate-producing bacteria can lead to D-lactic acidosis, also referred to as D-lactate encephalopathy, with severe neurologic impairment. Antibiotic treatments for D-lactic acidosis in children with SBS offer often only short-term relief. Here, we present the case of a boy with SBS who developed recurrent episodes of D-lactic acidosis even under continuous cycling antibiotic treatment. Microbiological analyses were used to detect the presence of D-lactate-producing species in the stool samples. A probiotic cocktail was introduced to alter the intestinal microbiota. During follow-up under treatment with probiotics, the patient remained stable, and there was no additional need for antibiotic therapy for more than a year. Stool composition of the patient was sequenced regularly over that period. His microbiota profile changed completely in species richness, and a clustering of species according to probiotic usage was seen. Importantly, D-lactate-producing strains disappeared within a few weeks after probiotic introduction and were no longer detected in the subsequent follow-up specimens.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

UniBE Contributor:

Yilmaz, Bahtiyar; Schibli, Susanne; Macpherson, Andrew and Sokollik, Christiane

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0031-4005

Publisher:

American Academy of Pediatrics

Language:

English

Submitter:

Thi Thao Anh Pham

Date Deposited:

04 Feb 2019 14:59

Last Modified:

04 Feb 2019 14:59

Publisher DOI:

10.1542/peds.2018-0337

PubMed ID:

30089656

BORIS DOI:

10.7892/boris.122380

URI:

https://boris.unibe.ch/id/eprint/122380

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