Bone in the breast? Long term toxicity 21 years after interstitial brachytherapy as a boost.

Imboden, Sara; Knabben, Laura Michelle Tatjana; Mueller, Michael; Günthert, Andreas R; Lössl, Kristina (2018). Bone in the breast? Long term toxicity 21 years after interstitial brachytherapy as a boost. Reports of practical oncology and radiotherapy, 23(5), pp. 337-340. Elsevier 10.1016/j.rpor.2018.06.002

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An 81-year-old patient developed an exulcerous tumor in her left breast 21 years after breast cancer treatment with lumpectomy and adjuvant radiotherapy. At the time of the initial treatment 21 years ago, whole breast irradiation was performed with a prescribed dose of 48 Gy and a maximal dose of 69 Gy. In addition, the patient received a 14.7 Gy boost with multicatheter brachytherapy as partial breast irradiation. In general, fat necrosis after radiotherapy, surgery or trauma is a minor problem for patients, but can lead to diagnostic difficulties. The incidence varies: the literature indicates that it occurs in up to 34% of cases. The direct pathogenesis is not clear; it can be due to high radiation dose to the breast, dosimetric inhomogeneities or surgical complications (seromas and inflammation). The tumor in the case described here, occurring more than two decades after the primary treatment, is a rarity in this extent and is an unusual clinical, radiological, and histological finding. It provides a good example of the need for an individualized approach to treatment.

Item Type:	Journal Article (Further Contribution)
Division/Institute:	04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology
UniBE Contributor:	Imboden, Sara, Knabben, Laura Michelle Tatjana, Mueller, Michael, Lössl, Kristina
Subjects:	600 Technology > 610 Medicine & health
ISSN:	1507-1367
Publisher:	Elsevier
Language:	English
Submitter:	Beatrice Scheidegger
Date Deposited:	15 Jan 2019 11:32
Last Modified:	05 Dec 2022 15:22
Publisher DOI:	10.1016/j.rpor.2018.06.002
PubMed ID:	30127673
Uncontrolled Keywords:	Breast cancer Breast conservation Fat necrosis Partial breast irradiation Radiotherapy
URI:	https://boris.unibe.ch/id/eprint/122394