Variability of Tidal Breathing Parameters in Preterm Infants and Associations with Respiratory Morbidity during Infancy: A Cohort Study.

Usemann, Jakob; Suter, Andrea; Zannin, Emanuela; Proietti, Elena; Fouzas, Sotirios; Schulzke, Sven; Latzin, Philipp; Frey, Urs (2019). Variability of Tidal Breathing Parameters in Preterm Infants and Associations with Respiratory Morbidity during Infancy: A Cohort Study. Journal of pediatrics, 205, 61-69.e1. Elsevier 10.1016/j.jpeds.2018.10.002

[img] Text
Usemann_et_all_2018_jpeds_Variability of Tidal Breathing Parameters in Preterm Infants and Associations with Respiratory Morbidity during Infancy A Cohort Study.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (1MB) | Request a copy

OBJECTIVE To test whether low variability of tidal volume (V) and capnographic indices are predictive of subsequent respiratory morbidity in preterm infants. STUDY DESIGN In a birth cohort of 133 preterm infants, lung function was performed at 44 weeks postmenstrual age. Associations between the coefficient of variation (CV) of V (CV) and of expired CO volume per breath (CV) with rehospitalization, wheeze, and inhalation therapy during infancy were assessed using logistic regression. Area under the curve (AUC) analysis was used to assess whether outcome prediction using bronchopulmonary dysplasia (BPD) classification was enhanced by CV or CV. RESULTS For each IQR decrease in CV (range, 4%-35%) and CV, (range, 5%-40%), the OR for rehospitalization increased by 2.25 (95% CI, 1.21-4.20) and 2.31 (95% CI, 1.20-4.45), respectively. The predictive value of BPD for rehospitalization was improved when CV or CV was added to the model, with the AUC increasing from 0.56 to 0.66 in both models. No association was found for the other outcomes. CONCLUSIONS Compared with BPD classification alone, including near-term variability of tidal breathing parameters improves the prediction of rehospitalization in infancy. These findings may inform parent counseling and monitoring strategies in preterm infants.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Pneumology

UniBE Contributor:

Usemann, Jakob; Proietti, Elena and Latzin, Philipp

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0022-3476

Publisher:

Elsevier

Language:

English

Submitter:

Romy Melanie Rodriguez Del Rio

Date Deposited:

04 Feb 2019 16:56

Last Modified:

17 Nov 2019 05:50

Publisher DOI:

10.1016/j.jpeds.2018.10.002

PubMed ID:

30416016

Uncontrolled Keywords:

bronchopulmonary dysplasia chronic lung disease lung function morbidity newborn prospective

BORIS DOI:

10.7892/boris.122434

URI:

https://boris.unibe.ch/id/eprint/122434

Actions (login required)

Edit item Edit item
Provide Feedback