Maturation of endogenous glucose production in preterm and term calves

Steinhoff-Wagner, J.; Gors, S.; Junghans, P.; Bruckmaier, R.M.; Kanitz, E.; Metges, C.C.; Hammon, H.M. (2011). Maturation of endogenous glucose production in preterm and term calves. Journal of dairy science, 94(10), pp. 5111-23. Savoy, Ill.: American Dairy Science Association 10.3168/jds.2011-4355

Full text not available from this repository. (Request a copy)

Glucose disposability is often impaired in neonatal calves and even more in preterm calves. The objective of this study was to investigate ontogenic maturation of endogenous glucose production (eGP) in calves and its effects on postnatal glucose homeostasis. Calves (n = 7 per group) were born preterm (PT; delivered by section 9 d before term) or at term (T; spontaneous vaginal delivery), or spontaneously born and fed colostrum for 4 d (TC). Blood samples were taken immediately after birth and before and 2h after feeding at 24h after birth (PT; T) or on d 4 of life (TC) to determine metabolic and endocrine changes. After birth (PT and T) or on d 3 of life (TC), fasted calves were gavaged with deuterium-labeled water to determine gluconeogenesis (GNG) and intravenously infused with [U(13)C]-glucose to measure eGP and glucose oxidation (GOx) in blood plasma. After slaughter at 26h after birth (PT, T) or on d 4 of life (TC), glycogen concentrations in liver and hepatic mRNA concentrations and enzyme activities of pyruvate carboxylase, phosphoenolpyruvate carboxykinase (PEPCK), and glucose-6-phosphatase were measured. Preterm calves had the lowest plasma concentrations of cortisol and 3,5,3'-triiodothyronine at birth. Plasma glucose concentrations from d 1 to 2 decreased more, but plasma concentrations of lactate and urea and glucagon:insulin ratio were higher in PT than in T and TC calves. The eGP, GNG, GOx, as well as hepatic glycogen concentrations and PEPCK activities, were lowest in PT calves. Results indicate impaired glucose homeostasis due to decreased eGP in PT calves and maturation of eGP with ontogenic development.

Item Type:

Journal Article (Original Article)


05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Physiology

UniBE Contributor:

Bruckmaier, Rupert




American Dairy Science Association




Factscience Import

Date Deposited:

04 Oct 2013 14:32

Last Modified:

21 Jan 2014 15:05

Publisher DOI:


Web of Science ID:


URI: (FactScience: 218562)

Actions (login required)

Edit item Edit item
Provide Feedback