Mapping of the Available Chemical Space versus the Chemical Universe of Lead-Like Compounds

Lin, Arkadii; Horvath, Dragos; Afonina, Valentina; Marcou, Gilles; Reymond, Jean-Louis; Varnek, Alexandre (2018). Mapping of the Available Chemical Space versus the Chemical Universe of Lead-Like Compounds. ChemMedChem, 13(6), pp. 540-554. Wiley-VCH 10.1002/cmdc.201700561

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This is, to our knowledge, the most comprehensive analysis to date based on generative topographic mapping (GTM) of fragment‐like chemical space (40 million molecules with no more than 17 heavy atoms, both from the theoretically enumerated GDB‐17 and real‐world PubChem/ChEMBL databases). The challenge was to prove that a robust map of fragment‐like chemical space can actually be built, in spite of a limited (≪105) maximal number of compounds (“frame set”) usable for fitting the GTM manifold. An evolutionary map building strategy has been updated with a “coverage check” step, which discards manifolds failing to accommodate compounds outside the frame set. The evolved map has a good propensity to separate actives from inactives for more than 20 external structure–activity sets. It was proven to properly accommodate the entire collection of 40 m compounds. Next, it served as a library comparison tool to highlight biases of real‐world molecules (PubChem and ChEMBL) versus the universe of all possible species represented by FDB‐17, a fragment‐like subset of GDB‐17 containing 10 million molecules. Specific patterns, proper to some libraries and absent from others (diversity holes), were highlighted.

Item Type:

Journal Article (Original Article)


08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Reymond, Jean-Louis


500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry








Sandra Tanja Zbinden Di Biase

Date Deposited:

19 Dec 2018 12:13

Last Modified:

22 Oct 2019 18:34

Publisher DOI:





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