Synthesis of Lipid-Linked Oligosaccharides (LLOs) and Their Phosphonate Analogues as Probes To Study Protein Glycosylation Enzymes

Boilevin, Jérémy M.; Reymond, Jean-Louis (2018). Synthesis of Lipid-Linked Oligosaccharides (LLOs) and Their Phosphonate Analogues as Probes To Study Protein Glycosylation Enzymes. Synthesis - journal of synthetic organic chemistry, 50(14), pp. 2631-2654. Thieme 10.1055/s-0037-1609735

[img] Text
s-0037-1609735.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (2MB) | Request a copy

Here we review chemical and chemoenzymatic methods for the synthesis of lipid-linked oligosaccharides (LLOs) and their phosphonate analogues, which serve as substrates and inhibitors to investigate the structure and mechanism of protein N-glycosylation enzymes. We emphasize how to overcome the challenges pertaining to the instability and difficult physicochemical properties of this class of compounds.

Item Type:

Journal Article (Review Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Boilevin, Jérémy Mathias and Reymond, Jean-Louis

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

0039-7881

Publisher:

Thieme

Language:

English

Submitter:

Sandra Tanja Zbinden Di Biase

Date Deposited:

19 Dec 2018 14:24

Last Modified:

24 Oct 2019 13:58

Publisher DOI:

10.1055/s-0037-1609735

BORIS DOI:

10.7892/boris.122700

URI:

https://boris.unibe.ch/id/eprint/122700

Actions (login required)

Edit item Edit item
Provide Feedback