%PDF-1.3
1 0 obj
<<
/Kids [ 3 0 R 4 0 R 5 0 R 6 0 R 7 0 R 8 0 R 9 0 R 10 0 R 11 0 R 12 0 R 13 0 R 14 0 R 15 0 R 16 0 R 17 0 R 18 0 R ]
/Type /Pages
/Count 16
>>
endobj
2 0 obj
<<
/Producer (PyPDF2)
>>
endobj
3 0 obj
<<
/Contents 23 0 R
/Parent 1 0 R
/Resources <<
/Properties <<
/MC0 24 0 R
>>
/ColorSpace <<
/CS4 26 0 R
/CS3 30 0 R
/CS2 32 0 R
/CS1 34 0 R
/CS0 27 0 R
>>
/XObject <<
/Fm0 36 0 R
/Fm1 38 0 R
/Im3 49 0 R
/Im2 53 0 R
/Im1 57 0 R
/Im0 61 0 R
/Xi0 65 0 R
>>
/Font <<
/C2_0 70 0 R
/T1_4 78 0 R
/T1_2 83 0 R
/T1_3 88 0 R
/T1_0 93 0 R
/T1_1 97 0 R
/TT1 101 0 R
/TT0 105 0 R
/TT2 107 0 R
/F2 111 0 R
/F1 112 0 R
>>
/ProcSet [ /Text /ImageC /ImageB /PDF /ImageI ]
/ExtGState <<
/GS1 37 0 R
/GS0 39 0 R
>>
>>
/Trans <<
>>
/Rotate 0
/MediaBox [ 0 0 612 792 ]
/Annots [ 113 0 R 115 0 R 117 0 R 119 0 R 121 0 R 123 0 R 126 0 R 129 0 R 132 0 R ]
/Type /Page
>>
endobj
4 0 obj
<<
/Contents 443 0 R
/Parent 1 0 R
/Tabs /W
/Resources <<
/ColorSpace <<
/CS0 447 0 R
>>
/XObject <<
/Fm0 449 0 R
/Xi1 451 0 R
>>
/Font <<
/T1_4 456 0 R
/T1_2 461 0 R
/T1_3 466 0 R
/T1_0 470 0 R
/T1_1 474 0 R
/TT1 479 0 R
/TT0 483 0 R
>>
/ProcSet [ /PDF /Text /ImageB /ImageC /ImageI ]
/ExtGState <<
/GS1 487 0 R
/GS0 450 0 R
>>
>>
/Rotate 0
/CropBox [ 0 0 612 792 ]
/MediaBox [ 0 0 612 792 ]
/TrimBox [ 0 0 612 792 ]
/Annots 488 0 R
/ArtBox [ 0 0 612 792 ]
/BleedBox [ 0 0 612 792 ]
/Type /Page
/Thumb 495 0 R
>>
endobj
5 0 obj
<<
/Contents 498 0 R
/Parent 1 0 R
/Tabs /W
/Resources <<
/Font <<
/T1_6 474 0 R
/T1_4 502 0 R
/T1_5 505 0 R
/T1_2 508 0 R
/T1_3 511 0 R
/T1_0 470 0 R
/T1_1 512 0 R
/TT1 479 0 R
/TT0 483 0 R
/TT2 513 0 R
>>
/Properties <<
/MC0 517 0 R
>>
/ColorSpace <<
/CS0 447 0 R
>>
/XObject <<
/Fm0 519 0 R
/Xi2 451 0 R
/Im0 524 0 R
>>
/ProcSet [ /PDF /Text /ImageB /ImageC /ImageI ]
/ExtGState <<
/GS1 487 0 R
/GS0 450 0 R
>>
>>
/Rotate 0
/CropBox [ 0 0 612 792 ]
/MediaBox [ 0 0 612 792 ]
/TrimBox [ 0 0 612 792 ]
/Annots 525 0 R
/ArtBox [ 0 0 612 792 ]
/BleedBox [ 0 0 612 792 ]
/Type /Page
/Thumb 532 0 R
>>
endobj
6 0 obj
<<
/Contents 533 0 R
/Parent 1 0 R
/Tabs /W
/Resources <<
/ColorSpace <<
/CS0 447 0 R
>>
/XObject <<
/Fm0 449 0 R
/Xi3 451 0 R
>>
/Font <<
/T1_4 456 0 R
/T1_2 466 0 R
/T1_3 461 0 R
/T1_0 470 0 R
/T1_1 474 0 R
/TT1 479 0 R
/TT0 483 0 R
/C2_0 537 0 R
>>
/ProcSet [ /PDF /Text /ImageB /ImageC /ImageI ]
/ExtGState <<
/GS1 487 0 R
/GS0 450 0 R
>>
>>
/Rotate 0
/CropBox [ 0 0 612 792 ]
/MediaBox [ 0 0 612 792 ]
/TrimBox [ 0 0 612 792 ]
/Annots 545 0 R
/ArtBox [ 0 0 612 792 ]
/BleedBox [ 0 0 612 792 ]
/Type /Page
/Thumb 552 0 R
>>
endobj
7 0 obj
<<
/Contents 553 0 R
/Parent 1 0 R
/Tabs /W
/Resources <<
/ColorSpace <<
/CS0 447 0 R
>>
/XObject <<
/Fm0 519 0 R
/Xi4 451 0 R
>>
/Font <<
/T1_2 461 0 R
/T1_3 456 0 R
/T1_0 470 0 R
/T1_1 474 0 R
/TT1 479 0 R
/TT0 483 0 R
/TT2 513 0 R
/C2_0 537 0 R
>>
/ProcSet [ /PDF /Text /ImageB /ImageC /ImageI ]
/ExtGState <<
/GS2 557 0 R
/GS1 487 0 R
/GS0 450 0 R
>>
>>
/Rotate 0
/CropBox [ 0 0 612 792 ]
/MediaBox [ 0 0 612 792 ]
/TrimBox [ 0 0 612 792 ]
/Annots 558 0 R
/ArtBox [ 0 0 612 792 ]
/BleedBox [ 0 0 612 792 ]
/Type /Page
/Thumb 565 0 R
>>
endobj
8 0 obj
<<
/Contents 566 0 R
/Parent 1 0 R
/Tabs /W
/Resources <<
/Font <<
/T1_4 461 0 R
/T1_2 570 0 R
/T1_3 474 0 R
/T1_0 470 0 R
/T1_1 456 0 R
/TT1 479 0 R
/TT0 483 0 R
/TT2 513 0 R
/C2_0 537 0 R
>>
/Properties <<
/MC0 571 0 R
>>
/ColorSpace <<
/CS0 447 0 R
>>
/XObject <<
/Fm0 449 0 R
/Xi5 451 0 R
/Im0 573 0 R
>>
/ProcSet [ /PDF /Text /ImageB /ImageC /ImageI ]
/ExtGState <<
/GS1 487 0 R
/GS0 450 0 R
>>
>>
/Rotate 0
/CropBox [ 0 0 612 792 ]
/MediaBox [ 0 0 612 792 ]
/TrimBox [ 0 0 612 792 ]
/Annots 574 0 R
/ArtBox [ 0 0 612 792 ]
/BleedBox [ 0 0 612 792 ]
/Type /Page
/Thumb 581 0 R
>>
endobj
9 0 obj
<<
/Contents 582 0 R
/Parent 1 0 R
/Tabs /W
/Resources <<
/Font <<
/T1_4 586 0 R
/T1_5 587 0 R
/T1_2 456 0 R
/T1_3 461 0 R
/T1_0 470 0 R
/T1_1 474 0 R
/TT1 479 0 R
/TT0 483 0 R
/TT2 513 0 R
/C2_0 537 0 R
>>
/Properties <<
/MC1 589 0 R
/MC0 591 0 R
>>
/ColorSpace <<
/CS0 447 0 R
>>
/XObject <<
/Xi6 451 0 R
/Fm0 519 0 R
/Im3 593 0 R
/Im2 594 0 R
/Im1 595 0 R
/Im0 596 0 R
>>
/ProcSet [ /PDF /Text /ImageB /ImageC /ImageI ]
/ExtGState <<
/GS1 487 0 R
/GS0 450 0 R
>>
>>
/Rotate 0
/CropBox [ 0 0 612 792 ]
/MediaBox [ 0 0 612 792 ]
/TrimBox [ 0 0 612 792 ]
/Annots 597 0 R
/ArtBox [ 0 0 612 792 ]
/BleedBox [ 0 0 612 792 ]
/Type /Page
/Thumb 604 0 R
>>
endobj
10 0 obj
<<
/Contents 605 0 R
/Parent 1 0 R
/Tabs /W
/Resources <<
/Font <<
/T1_4 609 0 R
/T1_2 456 0 R
/T1_3 461 0 R
/T1_0 470 0 R
/T1_1 474 0 R
/TT1 479 0 R
/TT0 483 0 R
/TT2 513 0 R
/C2_0 537 0 R
>>
/Properties <<
/MC0 610 0 R
>>
/ColorSpace <<
/CS0 447 0 R
>>
/XObject <<
/Fm0 449 0 R
/Xi7 451 0 R
/Im2 612 0 R
/Im1 613 0 R
/Im0 614 0 R
>>
/ProcSet [ /PDF /Text /ImageB /ImageC /ImageI ]
/ExtGState <<
/GS1 487 0 R
/GS0 450 0 R
>>
>>
/Rotate 0
/CropBox [ 0 0 612 792 ]
/MediaBox [ 0 0 612 792 ]
/TrimBox [ 0 0 612 792 ]
/Annots 615 0 R
/ArtBox [ 0 0 612 792 ]
/BleedBox [ 0 0 612 792 ]
/Type /Page
/Thumb 622 0 R
>>
endobj
11 0 obj
<<
/Contents 623 0 R
/Parent 1 0 R
/Tabs /W
/Resources <<
/Font <<
/T1_2 627 0 R
/T1_0 470 0 R
/T1_1 456 0 R
/TT1 479 0 R
/TT0 483 0 R
/TT2 513 0 R
/C2_0 537 0 R
/C2_1 628 0 R
>>
/Properties <<
/MC0 636 0 R
>>
/ColorSpace <<
/CS0 447 0 R
>>
/XObject <<
/Fm0 519 0 R
/Im4 638 0 R
/Im3 639 0 R
/Im2 640 0 R
/Im1 641 0 R
/Im0 642 0 R
/Xi8 451 0 R
>>
/ProcSet [ /PDF /Text /ImageB /ImageC /ImageI ]
/ExtGState <<
/GS1 487 0 R
/GS0 450 0 R
>>
>>
/Rotate 0
/CropBox [ 0 0 612 792 ]
/MediaBox [ 0 0 612 792 ]
/TrimBox [ 0 0 612 792 ]
/Annots 643 0 R
/ArtBox [ 0 0 612 792 ]
/BleedBox [ 0 0 612 792 ]
/Type /Page
/Thumb 650 0 R
>>
endobj
12 0 obj
<<
/Contents 651 0 R
/Parent 1 0 R
/Tabs /W
/Resources <<
/Font <<
/T1_4 655 0 R
/T1_2 656 0 R
/T1_3 657 0 R
/T1_0 470 0 R
/T1_1 456 0 R
/TT1 479 0 R
/TT0 483 0 R
/TT2 513 0 R
/C2_0 537 0 R
>>
/Properties <<
/MC1 661 0 R
/MC0 663 0 R
>>
/ColorSpace <<
/CS0 447 0 R
>>
/XObject <<
/Fm0 449 0 R
/Im0 665 0 R
/Im1 666 0 R
/Xi9 451 0 R
>>
/ProcSet [ /PDF /Text /ImageB /ImageC /ImageI ]
/ExtGState <<
/GS1 487 0 R
/GS0 450 0 R
>>
>>
/Rotate 0
/CropBox [ 0 0 612 792 ]
/MediaBox [ 0 0 612 792 ]
/TrimBox [ 0 0 612 792 ]
/Annots 667 0 R
/ArtBox [ 0 0 612 792 ]
/BleedBox [ 0 0 612 792 ]
/Type /Page
/Thumb 674 0 R
>>
endobj
13 0 obj
<<
/Contents 675 0 R
/Parent 1 0 R
/Tabs /W
/Resources <<
/Font <<
/T1_4 679 0 R
/T1_5 680 0 R
/T1_2 461 0 R
/T1_3 456 0 R
/T1_0 470 0 R
/T1_1 474 0 R
/TT1 479 0 R
/TT0 483 0 R
/TT2 513 0 R
>>
/Properties <<
/MC0 681 0 R
>>
/ColorSpace <<
/CS0 447 0 R
>>
/XObject <<
/Fm0 519 0 R
/Xi10 451 0 R
/Im0 683 0 R
>>
/ProcSet [ /PDF /Text /ImageB /ImageC /ImageI ]
/ExtGState <<
/GS1 487 0 R
/GS0 450 0 R
>>
>>
/Rotate 0
/CropBox [ 0 0 612 792 ]
/MediaBox [ 0 0 612 792 ]
/TrimBox [ 0 0 612 792 ]
/Annots 684 0 R
/ArtBox [ 0 0 612 792 ]
/BleedBox [ 0 0 612 792 ]
/Type /Page
/Thumb 691 0 R
>>
endobj
14 0 obj
<<
/Contents 692 0 R
/Parent 1 0 R
/Tabs /W
/Resources <<
/Font <<
/T1_4 696 0 R
/T1_5 697 0 R
/T1_2 456 0 R
/T1_3 461 0 R
/T1_0 470 0 R
/T1_1 474 0 R
/TT1 479 0 R
/TT0 483 0 R
/TT2 513 0 R
/C2_0 537 0 R
>>
/Properties <<
/MC0 700 0 R
>>
/ColorSpace <<
/CS0 447 0 R
>>
/XObject <<
/Fm0 449 0 R
/Xi11 451 0 R
/Im0 702 0 R
>>
/ProcSet [ /PDF /Text /ImageB /ImageC /ImageI ]
/ExtGState <<
/GS1 487 0 R
/GS0 450 0 R
>>
>>
/Rotate 0
/CropBox [ 0 0 612 792 ]
/MediaBox [ 0 0 612 792 ]
/TrimBox [ 0 0 612 792 ]
/Annots 703 0 R
/ArtBox [ 0 0 612 792 ]
/BleedBox [ 0 0 612 792 ]
/Type /Page
/Thumb 710 0 R
>>
endobj
15 0 obj
<<
/Contents 711 0 R
/Parent 1 0 R
/Tabs /W
/Resources <<
/ColorSpace <<
/CS0 447 0 R
>>
/XObject <<
/Fm0 519 0 R
/Xi12 451 0 R
>>
/Font <<
/T1_2 461 0 R
/T1_3 456 0 R
/T1_0 470 0 R
/T1_1 474 0 R
/TT1 479 0 R
/TT0 483 0 R
>>
/ProcSet [ /PDF /Text /ImageB /ImageC /ImageI ]
/ExtGState <<
/GS1 487 0 R
/GS0 450 0 R
>>
>>
/Rotate 0
/CropBox [ 0 0 612 792 ]
/MediaBox [ 0 0 612 792 ]
/TrimBox [ 0 0 612 792 ]
/Annots 715 0 R
/ArtBox [ 0 0 612 792 ]
/BleedBox [ 0 0 612 792 ]
/Type /Page
/Thumb 722 0 R
>>
endobj
16 0 obj
<<
/Contents 723 0 R
/Parent 1 0 R
/Tabs /W
/Resources <<
/ColorSpace <<
/CS0 447 0 R
>>
/XObject <<
/Fm0 449 0 R
/Xi13 451 0 R
>>
/Font <<
/T1_4 466 0 R
/T1_2 461 0 R
/T1_3 456 0 R
/T1_0 470 0 R
/T1_1 474 0 R
/TT1 479 0 R
/TT0 483 0 R
>>
/ProcSet [ /PDF /Text /ImageB /ImageC /ImageI ]
/ExtGState <<
/GS1 487 0 R
/GS0 450 0 R
>>
>>
/Rotate 0
/CropBox [ 0 0 612 792 ]
/MediaBox [ 0 0 612 792 ]
/TrimBox [ 0 0 612 792 ]
/Annots 727 0 R
/ArtBox [ 0 0 612 792 ]
/BleedBox [ 0 0 612 792 ]
/Type /Page
/Thumb 734 0 R
>>
endobj
17 0 obj
<<
/Contents 735 0 R
/Parent 1 0 R
/Tabs /W
/Resources <<
/ColorSpace <<
/CS0 447 0 R
>>
/XObject <<
/Fm0 519 0 R
/Xi14 451 0 R
>>
/Font <<
/C2_0 739 0 R
/T1_2 461 0 R
/T1_3 456 0 R
/T1_0 470 0 R
/T1_1 474 0 R
/TT1 479 0 R
/TT0 483 0 R
>>
/ProcSet [ /PDF /Text /ImageB /ImageC /ImageI ]
/ExtGState <<
/GS1 487 0 R
/GS0 450 0 R
>>
>>
/Rotate 0
/CropBox [ 0 0 612 792 ]
/MediaBox [ 0 0 612 792 ]
/TrimBox [ 0 0 612 792 ]
/Annots 747 0 R
/ArtBox [ 0 0 612 792 ]
/BleedBox [ 0 0 612 792 ]
/Type /Page
/Thumb 754 0 R
>>
endobj
18 0 obj
<<
/Contents 755 0 R
/Parent 1 0 R
/Tabs /W
/Resources <<
/ColorSpace <<
/CS0 447 0 R
>>
/XObject <<
/Fm0 449 0 R
/Xi15 451 0 R
>>
/Font <<
/T1_2 461 0 R
/T1_3 456 0 R
/T1_0 470 0 R
/T1_1 474 0 R
/TT1 479 0 R
/TT0 483 0 R
>>
/ProcSet [ /PDF /Text /ImageB /ImageC /ImageI ]
/ExtGState <<
/GS1 487 0 R
/GS0 450 0 R
>>
>>
/Rotate 0
/CropBox [ 0 0 612 792 ]
/MediaBox [ 0 0 612 792 ]
/TrimBox [ 0 0 612 792 ]
/Annots 759 0 R
/ArtBox [ 0 0 612 792 ]
/BleedBox [ 0 0 612 792 ]
/Type /Page
/Thumb 767 0 R
>>
endobj
19 0 obj
<<
/D [ 0 /Fit ]
/S /GoTo
>>
endobj
20 0 obj
<<
/Parent 21 0 R
/Title (1)
/A 19 0 R
>>
endobj
21 0 obj
<<
/Count 1
/First 20 0 R
/Last 20 0 R
>>
endobj
22 0 obj
<<
/Type /Catalog
/Pages 1 0 R
/Outlines 21 0 R
>>
endobj
23 0 obj
<<
/Length 21983
>>
stream
q
1 0 0 1 0 0 cm
BT
/F1 12 Tf
14.4 TL
ET
BT
/F2 9 Tf
10.8 TL
ET
q
0 1 -1 0 15 56 cm
BT
1 0 0 1 0 0 Tm
1 0 0 1 0 0 Tm
/F2 9 Tf
10.8 TL
0.2667 0.2667 0.2667 rg
(source\072 ) Tj
0.89 0 0.239 rg
(https\072\057\057doi\056org\05710\0567892\057boris\056122705) Tj
0.2667 0.2667 0.2667 rg
( \174 downloaded\072 29\0563\0562024) Tj
ET
Q
Q
q
q
/PlacedGraphic /MC0 BDC
EMC
q
221.15 32.576 39.093 13.682 re
W
n
/CS0 cs
0.668 0.698 0.672 scn
/GS0 gs
q
1 0 0 1 222.2603 46.1153 cm
0 0 m
36.926 -0.066 l
37.441 -0.066 37.902 0.011 37.902 -1.096 c
37.857 -13.257 l
-0.932 -13.257 l
-0.932 -1.051 l
-0.932 -0.506 -0.879 0 0 0 c
f
Q
1 1 1 scn
q
1 0 0 1 232.3961 39.8936 cm
0 0 m
0.002 -2.453 -1.986 -4.443 -4.439 -4.444 c
-6.892 -4.445 -8.882 -2.458 -8.883 -0.006 c
-8.883 0 l
-8.885 2.452 -6.897 4.442 -4.444 4.443 c
-1.991 4.444 -0.001 2.458 0 0.005 c
h
f
Q
0 0.001 0 scn
q
1 0 0 1 230.1519 40.3888 cm
0 0 m
-0.127 0.278 -0.314 0.416 -0.56 0.416 c
-1.018 0.416 -1.248 0.114 -1.248 -0.49 c
-1.248 -1.095 -1.018 -1.396 -0.56 -1.396 c
-0.263 -1.396 -0.055 -1.25 0.063 -0.955 c
0.7 -1.286 l
0.404 -1.813 -0.041 -2.077 -0.633 -2.077 c
-1.09 -2.077 -1.456 -1.937 -1.732 -1.656 c
-2.006 -1.376 -2.144 -0.989 -2.144 -0.496 c
-2.144 -0.011 -2.004 0.374 -1.725 0.659 c
-1.446 0.944 -1.09 1.086 -0.659 1.086 c
-0.032 1.086 0.416 0.839 0.687 0.345 c
h
-2.929 0 m
-3.056 0.278 -3.246 0.416 -3.5 0.416 c
-3.949 0.416 -4.174 0.114 -4.174 -0.49 c
-4.174 -1.095 -3.949 -1.396 -3.5 -1.396 c
-3.204 -1.396 -2.992 -1.25 -2.865 -0.955 c
-2.242 -1.286 l
-2.539 -1.813 -2.984 -2.077 -3.578 -2.077 c
-4.036 -2.077 -4.402 -1.937 -4.678 -1.656 c
-4.953 -1.376 -5.091 -0.989 -5.091 -0.496 c
-5.091 -0.011 -4.949 0.374 -4.665 0.659 c
-4.381 0.944 -4.027 1.086 -3.603 1.086 c
-2.976 1.086 -2.527 0.839 -2.255 0.345 c
h
-5.12 2.459 m
-5.953 1.618 -6.369 0.633 -6.369 -0.497 c
-6.369 -1.627 -5.957 -2.604 -5.133 -3.427 c
-4.309 -4.251 -3.327 -4.663 -2.189 -4.663 c
-1.051 -4.663 -0.061 -4.247 0.78 -3.415 c
1.579 -2.642 1.978 -1.669 1.978 -0.497 c
1.978 0.667 1.572 1.654 0.761 2.466 c
-0.05 3.277 -1.034 3.683 -2.189 3.683 c
-3.344 3.683 -4.322 3.275 -5.12 2.459 c
1.413 3.122 m
2.398 2.137 2.89 0.931 2.89 -0.496 c
2.89 -1.922 2.406 -3.115 1.438 -4.075 c
0.411 -5.086 -0.803 -5.591 -2.204 -5.591 c
-3.588 -5.591 -4.781 -5.09 -5.783 -4.088 c
-6.785 -3.086 -7.286 -1.888 -7.286 -0.496 c
-7.286 0.897 -6.785 2.104 -5.783 3.122 c
-4.807 4.107 -3.614 4.601 -2.204 4.601 c
-0.777 4.601 0.428 4.107 1.413 3.122 c
f
Q
q
1 0 0 1 221.8819 45.9278 cm
0 0 m
37.626 0 l
37.848 0 38.029 -0.181 38.029 -0.401 c
38.029 -9.266 l
11.135 -9.266 l
10.149 -11.047 8.25 -12.257 6.07 -12.257 c
3.89 -12.257 1.991 -11.048 1.006 -9.266 c
-0.401 -9.266 l
-0.401 -0.401 l
-0.401 -0.181 -0.221 0 0 0 c
37.626 0.33 m
0 0.33 l
-0.404 0.33 -0.732 0.002 -0.732 -0.401 c
-0.732 -13.187 l
-0.732 -13.278 -0.658 -13.352 -0.567 -13.352 c
38.193 -13.352 l
38.285 -13.352 38.359 -13.278 38.359 -13.187 c
38.359 -0.401 l
38.359 0.002 38.031 0.33 37.626 0.33 c
f
Q
1 1 1 scn
q
1 0 0 1 240.6617 33.8018 cm
0 0 m
0.046 0 0.091 0.004 0.133 0.015 c
0.175 0.023 0.213 0.038 0.245 0.06 c
0.278 0.08 0.303 0.109 0.323 0.146 c
0.342 0.182 0.351 0.229 0.351 0.284 c
0.351 0.395 0.32 0.475 0.257 0.521 c
0.195 0.568 0.112 0.592 0.009 0.592 c
-0.509 0.592 l
-0.509 0 l
h
-0.028 0.916 m
0.057 0.916 0.127 0.937 0.181 0.977 c
0.236 1.017 0.263 1.081 0.263 1.172 c
0.263 1.223 0.254 1.265 0.236 1.295 c
0.217 1.328 0.193 1.354 0.163 1.371 c
0.133 1.39 0.098 1.402 0.059 1.409 c
0.019 1.416 -0.022 1.419 -0.064 1.419 c
-0.509 1.419 l
-0.509 0.916 l
h
0.033 1.788 m
0.136 1.788 0.229 1.779 0.314 1.762 c
0.399 1.743 0.472 1.713 0.532 1.672 c
0.593 1.631 0.64 1.576 0.673 1.507 c
0.706 1.44 0.723 1.356 0.723 1.253 c
0.723 1.146 0.698 1.055 0.649 0.983 c
0.6 0.909 0.526 0.851 0.429 0.805 c
0.563 0.766 0.662 0.699 0.728 0.604 c
0.794 0.507 0.827 0.393 0.827 0.256 c
0.827 0.148 0.806 0.054 0.763 -0.025 c
0.721 -0.105 0.664 -0.171 0.592 -0.221 c
0.52 -0.27 0.439 -0.309 0.347 -0.333 c
0.255 -0.356 0.161 -0.369 0.064 -0.369 c
-0.984 -0.369 l
-0.984 1.788 l
h
f
Q
q
1 0 0 1 241.5719 35.5899 cm
0 0 m
0.532 0 l
1.037 -0.852 l
1.539 0 l
2.068 0 l
1.268 -1.329 l
1.268 -2.156 l
0.792 -2.156 l
0.792 -1.316 l
h
f
Q
q
1 0 0 1 249.3067 35.5899 cm
0 0 m
0.901 -1.446 l
0.907 -1.446 l
0.907 0 l
1.351 0 l
1.351 -2.156 l
0.877 -2.156 l
-0.021 -0.713 l
-0.027 -0.713 l
-0.027 -2.156 l
-0.472 -2.156 l
-0.472 0 l
h
f
Q
q
1 0 0 1 252.4596 35.0157 cm
0 0 m
-0.029 0.046 -0.065 0.085 -0.107 0.12 c
-0.149 0.153 -0.197 0.181 -0.25 0.2 c
-0.304 0.219 -0.359 0.228 -0.418 0.228 c
-0.524 0.228 -0.615 0.208 -0.69 0.166 c
-0.765 0.125 -0.824 0.069 -0.871 0.001 c
-0.918 -0.069 -0.951 -0.148 -0.973 -0.237 c
-0.994 -0.325 -1.004 -0.417 -1.004 -0.513 c
-1.004 -0.603 -0.994 -0.69 -0.973 -0.776 c
-0.951 -0.861 -0.918 -0.939 -0.871 -1.007 c
-0.824 -1.075 -0.765 -1.13 -0.69 -1.171 c
-0.615 -1.213 -0.524 -1.233 -0.418 -1.233 c
-0.272 -1.233 -0.16 -1.189 -0.078 -1.101 c
0.004 -1.013 0.053 -0.895 0.072 -0.75 c
0.531 -0.75 l
0.519 -0.885 0.488 -1.007 0.437 -1.115 c
0.387 -1.225 0.321 -1.317 0.238 -1.395 c
0.155 -1.472 0.059 -1.529 -0.052 -1.57 c
-0.162 -1.61 -0.285 -1.63 -0.418 -1.63 c
-0.582 -1.63 -0.732 -1.602 -0.863 -1.544 c
-0.996 -1.487 -1.107 -1.407 -1.197 -1.308 c
-1.289 -1.206 -1.358 -1.088 -1.406 -0.952 c
-1.455 -0.816 -1.479 -0.669 -1.479 -0.513 c
-1.479 -0.352 -1.455 -0.201 -1.406 -0.063 c
-1.358 0.075 -1.289 0.195 -1.197 0.298 c
-1.107 0.4 -0.996 0.481 -0.863 0.54 c
-0.732 0.599 -0.582 0.628 -0.418 0.628 c
-0.299 0.628 -0.187 0.61 -0.08 0.576 c
0.024 0.542 0.119 0.492 0.203 0.427 c
0.287 0.36 0.356 0.28 0.41 0.183 c
0.465 0.087 0.5 -0.025 0.514 -0.15 c
0.053 -0.15 l
0.047 -0.095 0.027 -0.045 0 0 c
f
Q
q
1 0 0 1 254.2857 41.378 cm
0 0 m
0.001 -1.792 -1.45 -3.245 -3.242 -3.247 c
-5.034 -3.248 -6.488 -1.796 -6.489 -0.005 c
-6.489 0 l
-6.49 1.792 -5.039 3.245 -3.247 3.247 c
-1.455 3.248 -0.002 1.796 0 0.005 c
h
f
Q
0 0.001 0 scn
q
1 0 0 1 251.0455 44.4757 cm
0 0 m
-0.857 0 -1.582 -0.303 -2.175 -0.907 c
-2.336 -1.069 -2.476 -1.239 -2.596 -1.417 c
-1.151 -2.061 l
-1.021 -1.659 -0.64 -1.416 -0.178 -1.39 c
-0.178 -0.808 l
0.256 -0.808 l
0.256 -1.39 l
0.555 -1.404 0.882 -1.485 1.205 -1.736 c
0.708 -2.246 l
0.525 -2.116 0.294 -2.024 0.062 -2.024 c
-0.125 -2.024 -0.391 -2.082 -0.391 -2.318 c
-0.391 -2.354 -0.378 -2.386 -0.355 -2.413 c
0.127 -2.628 l
0.454 -2.774 l
0.663 -2.868 0.863 -2.956 1.061 -3.044 c
2.996 -3.906 l
3.061 -3.653 3.092 -3.384 3.092 -3.098 c
3.092 -2.235 2.789 -1.506 2.186 -0.907 c
1.585 -0.303 0.857 0 0 0 c
-2.932 -2.083 m
-3.045 -2.401 -3.101 -2.739 -3.101 -3.098 c
-3.101 -3.936 -2.796 -4.658 -2.185 -5.27 c
-1.573 -5.881 -0.845 -6.186 0 -6.186 c
0.846 -6.186 1.579 -5.877 2.203 -5.261 c
2.412 -5.059 2.584 -4.838 2.719 -4.6 c
1.295 -3.966 l
1.197 -4.444 0.772 -4.769 0.256 -4.807 c
0.256 -5.389 l
-0.178 -5.389 l
-0.178 -4.807 l
-0.602 -4.802 -1.012 -4.627 -1.325 -4.354 c
-0.805 -3.829 l
-0.555 -4.065 -0.303 -4.17 0.039 -4.17 c
0.26 -4.17 0.506 -4.084 0.506 -3.795 c
0.506 -3.693 0.466 -3.622 0.404 -3.568 c
0.044 -3.408 l
-0.404 -3.208 l
-0.626 -3.109 -0.814 -3.026 -1.003 -2.942 c
h
-0.009 0.68 m
1.049 0.68 1.945 0.314 2.676 -0.415 c
3.406 -1.147 3.773 -2.04 3.773 -3.098 c
3.773 -4.155 3.413 -5.04 2.695 -5.751 c
1.932 -6.5 1.031 -6.874 -0.009 -6.874 c
-1.037 -6.874 -1.923 -6.503 -2.667 -5.761 c
-3.41 -5.019 -3.782 -4.131 -3.782 -3.098 c
-3.782 -2.065 -3.41 -1.171 -2.667 -0.415 c
-1.942 0.314 -1.056 0.68 -0.009 0.68 c
f
Q
1 1 1 scn
q
1 0 0 1 241.7901 44.7989 cm
0 0 m
1.932 0 3.499 -1.565 3.499 -3.498 c
3.499 -5.43 1.932 -6.996 0 -6.996 c
-1.932 -6.996 -3.498 -5.43 -3.498 -3.498 c
-3.498 -1.565 -1.932 0 0 0 c
f
Q
0 0.001 0 scn
q
1 0 0 1 242.8028 42.3126 cm
0 0 m
0 0.135 -0.109 0.244 -0.244 0.244 c
-1.789 0.244 l
-1.924 0.244 -2.033 0.135 -2.033 0 c
-2.033 -1.545 l
-1.602 -1.545 l
-1.602 -3.374 l
-0.431 -3.374 l
-0.431 -1.545 l
0 -1.545 l
h
f
Q
q
1 0 0 1 241.7862 43.8175 cm
0 0 m
0.292 0 0.528 -0.237 0.528 -0.528 c
0.528 -0.82 0.292 -1.058 0 -1.058 c
-0.292 -1.058 -0.529 -0.82 -0.529 -0.528 c
-0.529 -0.237 -0.292 0 0 0 c
f
Q
q
1 0 0 1 241.7906 44.4757 cm
0 0 m
0.857 0 1.586 -0.303 2.184 -0.907 c
2.79 -1.506 3.092 -2.235 3.092 -3.098 c
3.092 -3.967 2.796 -4.687 2.203 -5.261 c
1.579 -5.877 0.845 -6.186 0 -6.186 c
-0.845 -6.186 -1.573 -5.881 -2.184 -5.27 c
-2.796 -4.659 -3.101 -3.936 -3.101 -3.098 c
-3.101 -2.261 -2.792 -1.53 -2.175 -0.907 c
-1.582 -0.303 -0.857 0 0 0 c
-0.01 0.68 m
-1.056 0.68 -1.942 0.314 -2.666 -0.416 c
-3.41 -1.171 -3.782 -2.065 -3.782 -3.098 c
-3.782 -4.131 -3.41 -5.019 -2.666 -5.761 c
-1.923 -6.503 -1.037 -6.874 -0.01 -6.874 c
1.031 -6.874 1.932 -6.5 2.695 -5.751 c
3.414 -5.04 3.773 -4.155 3.773 -3.098 c
3.773 -2.04 3.407 -1.147 2.676 -0.416 c
1.945 0.314 1.05 0.68 -0.01 0.68 c
f
Q
Q
BT
/CS0 cs
0 0 0 scn
/GS1 gs
/T1_0 1 Tf
-0.012 Tc
6 0 0 6 263.1708 40.0763 Tm
[ (\251 2018 P) 40 (ompilio et al\056) 100 ( This w) 15 (ork is published and licensed b) 25 (y Do) 20 (ve Medical Press Limited\056) 100 ( The full terms of this license are a) 20 (vailable at https\072\057\057www\056do) 20 (vepress) -19.9 (\056com\057terms) -20 (\056) ] TJ
0 Tc
48.984 0 Td
( ) Tj
-0.012 Tc
-48.972 -1.083 Td
[ (php and incorporate the Creative Commons ) 40 (Attribution \226 Non Commercial \050unpor) -25 (ted\054) 100 ( v3\0560\051 License \050http\072\057\057creativecommons) -19.9 (\056or) 15 (g\057licenses\057b) 25 (y\055nc\0573\0560\057\051\056) 100.1 ( By accessing the w) 15 (ork) -11.9 ( ) ] TJ
-7.015 -1.083 Td
[ (you hereb) 25 (y accept the T) 49.9 (erms) -20 (\056) 100 ( Non\055commercial uses of the w) 15 (ork are permitted without an) 20.1 (y fur) -25 (ther permission from Do) 20 (ve Medical Press Limited\054) 100 ( pro) 20 (vided the w) 15 (ork is proper) -15 (ly attributed\056) 100 ( F) 40 (or) -12 ( ) ] TJ
0 -1.083 TD
[ (permission for commercial use of this w) 15.1 (ork\054) 100 ( please see paragraphs 4\0562 and 5 of our T) 50 (erms \050https\072\057\057www\056do) 20 (vepress) -19.9 (\056com\057terms) -20 (\056php\051\056) ] TJ
/TT0 1 Tf
0 Tc
8 0 0 8 221.15 49.3306 Tm
[ (Inf) 9.8 (ection and Drug Resistance 2018\07211 1767\2261782) ] TJ
0.217 0.52 0.68 scn
/GS0 gs
/T1_1 1 Tf
12 0 0 12 70.85 738.5301 Tm
(Infection and Drug Resistance) Tj
35.489 0 Td
(Dove) Tj
0.72 0.728 0.737 scn
(press) Tj
0.503 0.51 0.52 scn
/TT1 1 Tf
5 0 0 5 70.85 51.4534 Tm
[ (submit y) 25.8 (our man) 9.6 (uscript ) ] TJ
0.72 0.728 0.737 scn
/TT0 1 Tf
[ (\174 www) 59.8 (\056do) 10 (v) 20 (epr) 20 (ess\056com) ] TJ
0.217 0.52 0.68 scn
/T1_1 1 Tf
6 0 0 6 70.85 41.148 Tm
(Dove) Tj
0.72 0.728 0.737 scn
(press ) Tj
0 0 0 scn
/GS1 gs
/TT1 1 Tf
10 0 0 10 536.0797 47.9988 Tm
(1767) Tj
ET
q
0 g
/GS0 gs
/Fm0 Do
Q
BT
/TT0 1 Tf
0.208 Tc
10 0 0 10 428.2769 701.2408 Tm
[ (O) -0.6 (RIG) -0.6 (INAL) -0.6 ( RESEARCH) ] TJ
ET
q
0 g
/GS0 gs
0 Tc
/Fm1 Do
Q
q
113.65 36.772 10.142 10.143 re
W
n
q
/GS0 gs
10.14257 0 0 10.14257 113.65 36.77237 cm
/Im0 Do
Q
Q
q
/GS0 gs
10.143 0 0 10.143 145.75328 36.77194 cm
/Im1 Do
Q
q
/GS0 gs
10.76592 0 0 10.76592 129.13995 36.67142 cm
/Im2 Do
Q
q
/GS0 gs
10.12298 0 0 10.12298 162.24368 37.38703 cm
/Im3 Do
Q
BT
0.503 0.51 0.52 scn
/GS0 gs
/TT1 1 Tf
0 Tc
5 0 0 5 70.85 30.8748 Tm
(http\072) Tj
0.72 0.728 0.737 scn
2.249 0 Td
(\057\057dx\056doi\056org\05710\0562147\057IDR\056S168868) Tj
0 0 0 scn
/GS1 gs
/TT0 1 Tf
24 0 0 24 70.85 674.318 Tm
[ (P) 25.1 (eptide dendrimers as ) 101.6 (\223lead compounds\224 f) 11.7 (or ) ] TJ
0 -1.167 TD
[ (the tr) 20.2 (eatment of chr) 25.7 (onic lung inf) 9.9 (ections b) 10.1 (y ) ] TJ
/TT2 1 Tf
0 -1.167 TD
(Pseudomonas aeruginosa) Tj
/C2_0 1 Tf
9.431 0 Td
[ <0003004c005100030046005c00560057004c0046000300c000450055> 25.2 <00520056004c00560003005300440057004c0048005100570056001d> 100.7 <0003> ] TJ
/TT0 1 Tf
-9.431 -1.167 Td
[ (in vitr) 24.6 (o and in viv) 20.8 (o studies) ] TJ
0.042 Tc
11 0 0 11 70.85 510.742 Tm
[ (Aria) 0.6 (nna) 0.6 ( ) 0.5 (P) 25.5 (o) 0.5 (mpilio) ] TJ
-0.042 Tw
6.413 0 0 6.413 154.4221 514.405 Tm
(1\0542) Tj
0 Tw
11 0 0 11 70.85 496.7421 Tm
[ (Cris) 0.5 (tina) 0.6 ( Geminia) 0.6 (ni) ] TJ
-0.042 Tw
6.413 0 0 6.413 162.0367 500.4051 Tm
(1\0542) Tj
0 Tw
11 0 0 11 70.85 482.7421 Tm
[ (P) 0.6 (a) 0.5 (o) 0.6 (lo) 0.6 ( ) 0.5 (M) 0.6 (a) 0.5 (ntini) ] TJ
-0.042 Tw
6.413 0 0 6.413 137.4867 486.4051 Tm
(1\0542) Tj
0 Tw
11 0 0 11 70.85 468.7421 Tm
[ (This) 0.5 (s) 0.6 (a) 0.6 ( ) 0.5 (N) 0.5 ( ) 0.5 (Siriwa) 0.6 (r) 15.4 (d) 0.6 (ena) ] TJ
0 Tc
6.413 0 0 6.413 174.5175 472.4051 Tm
(3) Tj
0.042 Tc
11 0 0 11 70.85 454.7421 Tm
[ (Iva) 0.6 (n ) 0.5 (Di ) 0.5 (Bo) 0.5 (na) 35.7 (v) 20.4 (entura) ] TJ
0 Tc
6.413 0 0 6.413 169.7461 458.4051 Tm
(3) Tj
0.042 Tc
11 0 0 11 70.85 440.7421 Tm
[ (J) 20.4 (ea) 0.6 (n ) 0.5 (Lo) 0.6 (uis) 0.5 ( ) 0.6 (Re) 15.5 (ymo) 0.6 (nd) ] TJ
0 Tc
6.413 0 0 6.413 169.0352 444.4051 Tm
(3) Tj
0.042 Tc
11 0 0 11 70.85 426.7421 Tm
[ (Gio) 10.3 (va) 0.6 (nni ) 0.5 (Di ) 0.5 (Bo) 0.5 (na) 35.7 (v) 20.4 (entura) ] TJ
-0.042 Tw
6.413 0 0 6.413 193.2575 430.4051 Tm
(1\0542) Tj
0 Tc
0 Tw
4.664 0 0 4.664 70.85 412.9061 Tm
(1) Tj
0.042 Tc
8 0 0 8 73.3764 410.2421 Tm
[ (Depa) 0.6 (r) -19.7 (tment ) 0.5 (o) 0.6 (f M) 0.6 (ed) 0.6 (ica) 0.5 (l\054) 100.2 ( ) 0.5 (Ora) 0.6 (l\054) 141.9 ( ) ] TJ
-0.316 -1.187 Td
[ (a) 0.6 (nd) 0.6 ( ) 0.5 (Bio) 0.6 (techno) 0.5 (lo) 0.6 (g) 0.6 (ica) 0.6 (l ) 0.5 (Sciences) 0.5 (\054) 100.2 ( ) 0.5 (G) 41.8 ( ) ] TJ
0 -1.187 TD
[ (d) 0.6 (\222Ann) 10.1 (unzio) 0.6 ( ) 0.5 (Univ) 20.4 (ers) 0.6 (ity ) 0.5 (o) 0.6 (f ) 0.5 (Chieti\055) ] TJ
T*
[ (P) 25.5 (es) 0.6 (ca) 0.6 (ra) 0.6 (\054) 100.2 ( ) 0.5 (Chieti) ] TJ
/Span <<
/ActualText (\376\377\000\240)
>> BDC
( ) Tj
EMC
6.836 0 Td
[ (66100\054) 100.1 ( ) 0.6 (Ita) 0.6 (l) 9.8 (y\073) 100.4 ( ) ] TJ
0 Tc
4.664 0 0 4.664 169.8949 384.4061 Tm
(2) Tj
0.042 Tc
8 0 0 8 172.4213 381.7421 Tm
[ (Center ) 0.5 (o) 0.5 (f) 42.1 ( ) ] TJ
-12.696 -1.187 Td
[ (Excellence ) 0.5 (o) 0.5 (n ) 100.6 (Ag) 0.6 (ing) 0.6 ( ) 0.5 (a) 0.6 (nd) 0.6 ( ) 125.5 (T) 125.3 (ra) 0.6 (ns) 0.6 (la) 0.6 (tio) 0.6 (na) 0.6 (l) 41.7 ( ) ] TJ
T*
[ (M) 0.6 (ed) 0.6 (icine) -19.7 (\054) 100.2 ( ) 0.5 (G ) 0.5 (d) 0.6 (\222Ann) 10.1 (unzio) 0.5 ( ) 0.5 (Univ) 20.4 (ers) 0.6 (ity) 42 ( ) ] TJ
T*
[ (o) 0.6 (f ) 0.5 (Chieti\055P) 25.5 (es) 0.6 (ca) 0.6 (ra) 0.6 (\054) 100.2 ( ) 0.5 (Chieti\054) 100.2 ( ) 0.5 (Ita) 0.6 (l) 9.9 (y\073) 142.1 ( ) ] TJ
0 Tc
4.664 0 0 4.664 70.85 346.4061 Tm
(3) Tj
0.042 Tc
8 0 0 8 73.3764 343.7421 Tm
[ (Depa) 0.6 (r) -19.7 (tment ) 0.5 (o) 0.6 (f Chemis) 0.5 (tr) -29.4 (y a) 0.6 (nd) 42.2 ( ) ] TJ
-0.316 -1.187 Td
[ (Bio) 0.6 (chemis) 0.6 (tr) -29.4 (y) 80.4 (\054) 100.2 ( ) 0.5 (Univ) 20.3 (ers) 0.6 (ity ) 0.5 (o) 0.6 (f ) 0.5 (Bern\054) 141.8 ( ) ] TJ
T*
[ (Bern\054) 100.2 ( ) 0.5 (Switzerla) 0.5 (nd) ] TJ
ET
/CS0 CS
0 0 0 SCN
0.5 w
q
1 0 0 1 221.15 529.5361 cm
0 0 m
337 0 l
S
Q
q
1 0 0 1 221.15 174.0361 cm
0 0 m
337 0 l
S
Q
BT
/TT1 1 Tf
0 Tc
9 0 0 9 221.15 511.2861 Tm
(Aim\072) Tj
/T1_2 1 Tf
-0.056 Tw
[ ( ) 0.5 (In ) 0.5 (the present ) 0.5 (w) 40.1 (ork\054 the ) 0.5 (potential ) 0.5 (of the ) 0.5 (D\055enantiomeric ) 0.6 (dendrimers ) 0.5 (dG3KL ) 0.5 (and dTNS18 ) ] TJ
0.053 Tw
0 -1.444 TD
[ (w) 25 (as e) 25 (v) 25 (aluated in relation to tobram) 40 (ycin \050T) 80 (ob\051\054 for the de) 25 (v) 15 (elopment of no) 45 (v) 14.9 (el antibacterials to ) ] TJ
0 Tw
0 -1.444 TD
(treat ) Tj
/T1_3 1 Tf
(Pseudomonas aeruginosa) Tj
/T1_2 1 Tf
[ ( chronic lung infections in patients with c) 15 (ystic \037brosis\056) ] TJ
/TT1 1 Tf
0.01 Tc
-0.01 Tw
0 -1.444 TD
(Results\072) Tj
/T1_2 1 Tf
-0.032 Tw
[ ( ) 50 (The acti) 25 (vity of dendrimers ag) 5 (ainst planktonic ) ] TJ
/T1_3 1 Tf
[ (P) 200 (\056 aeruginosa) ] TJ
/T1_2 1 Tf
[ ( cells w) 25 (as less than ) 50.1 (T) 80 (ob) 10 ( ) ] TJ
-0.056 Tw
0 -1.444 TD
[ (ag) 5 (ainst three of the four strains tested \050median minimum inhibitor) -20 (y concentration \133MIC\135 8 vs) 10 ( ) ] TJ
0.009 Tc
-0.063 Tw
0 -1.444 TD
(1) Tj
/Span <<
/ActualText (\376\377\000\240)
>> BDC
( ) Tj
EMC
[ (\265g\057mL\054 respecti) 25.1 (v) 15.1 (el) 25.1 (y\051\054 b) -4.9 (ut 32\055fold higher ag) 5.1 (ainst the P) 15.2 (aPh32 strain isolated at posttransplan) ] TJ
0 Tc
0 Tw
(\055) Tj
0.01 Tc
-0.01 Tw
0 -1.444 TD
[ (tation stage\056 Results from comparati) 25 (v) 15 (e minimum bactericidal concentration\057MIC e) 25.1 (v) 24.9 (aluation) 10 ( ) ] TJ
0.104 Tw
0 -1.444 TD
[ (and ) 0.5 (time\226kill ) 0.5 (assa) 35 (y ) 0.5 (suggested a bactericidal ) 0.5 (mechanism ) 0.5 (for ) 0.5 (all ) 0.5 (test ) 0.5 (agents\056 ) 0.5 (Subinhibitor) -20 (y) 10 ( ) ] TJ
0.093 Tw
0 -1.444 TD
[ (concentrations of both dendrimers and ) 49.9 (T) 80 (ob signi\037cantl) 25 (y af) 25 (fected bio\037lm for) -20 (mation b) 25 (y all) 10 ( ) ] TJ
0.004 Tw
0 -1.444 TD
[ (strains in a dose\055dependent manner) 40 (\054 although the P) 15 (aPh26 strain\054 isolated during the chronic) 10 ( ) ] TJ
0.11 Tw
T*
[ (stage of infection\054 w) 25 (as par) -20 (ticularl) 25 (y susceptib) 20 (le to dendrimers\056 ) 49.6 (The acti) 25 (vity of dendrimers) 10 ( ) ] TJ
0.019 Tc
0.125 Tw
0 -1.444 TD
[ (ag) 4.6 (ainst prefor) -20.3 (med ) ] TJ
/T1_3 1 Tf
[ (P) 199.7 (\056 aeruginosa) ] TJ
/T1_2 1 Tf
[ ( bio\037lm w) 24.7 (as generall) 24.6 (y comparab) 19.7 (le to ) 49.6 (T) 79.7 (ob\054 considering) 19 ( ) ] TJ
0.01 Tc
0.001 Tw
0 -1.444 TD
[ (both dispersion and viability of bio\037lm\056 P) 15 (ar) -20 (ticularl) 25 (y) 85 (\054 e) 15 (xposure to the test agent at 10 ) ] TJ
/T1_4 1 Tf
0 Tc
0 Tw
(\037) Tj
/T1_2 1 Tf
0.01 Tc
0.001 Tw
35.275 0 Td
[ ( MIC) 10 ( ) ] TJ
-0.034 Tw
-35.275 -1.444 Td
(caused signi\037cant bio\037lm death \050) Tj
/T1_4 1 Tf
0 Tc
0 Tw
(\036) Tj
/T1_2 1 Tf
0.01 Tc
-0.034 Tw
14.019 0 Td
[ (90\045\054 e) 25 (v) 15 (en to eradication\051\054 though with strain\055speci\037c dif) ] TJ
0 Tc
0 Tw
(\055) Tj
0.01 Tc
0.009 Tw
-14.019 -1.444 Td
[ (ferences\056 ) 0.5 (Single administration of dendrimers ) 0.5 (or ) 50.4 (T) 80 (ob at 10 ) ] TJ
/T1_4 1 Tf
0 Tc
0 Tw
24.2 0 Td
(\037) Tj
/T1_2 1 Tf
0.01 Tc
0.009 Tw
0.559 0 Td
[ ( MIC w) 25 (as not ) 0.5 (to) 19.9 (xic ) 0.5 (in ) ] TJ
/T1_3 1 Tf
-0.01 Tw
9.226 0 Td
[ (Galleria) 10 ( ) ] TJ
-33.985 -1.444 Td
(mellonella) Tj
/T1_2 1 Tf
-0.011 Tw
[ ( w) 25 (ax\055moth lar) -19.9 (v) 24.9 (ae o) 45 (v) 15 (er 96) ] TJ
/Span <<
/ActualText (\376\377\000\240)
>> BDC
( ) Tj
EMC
[ (hours\056 Ho) 40 (w) 34.9 (e) 25.1 (v) 14.9 (er) 40 (\054 contraril) 25 (y to ) 49.9 (T) 80 (ob\054 dendrimers w) 35 (ere not) 9.9 ( ) ] TJ
0.04 Tw
T*
[ (protecti) 25 (v) 15 (e ag) 4.9 (ainst systemic infection caused b) 25 (y ) ] TJ
/T1_3 1 Tf
[ (P) 200 (\056 aeruginosa) ] TJ
/T1_2 1 Tf
( in ) Tj
/T1_3 1 Tf
[ (G) 25 (\056 mellonella) ] TJ
/T1_2 1 Tf
[ (\056 Kinetics of) 10 ( ) ] TJ
/T1_3 1 Tf
0.07 Tw
0 -1.444 TD
[ (P) 200 (\056 aeruginosa) ] TJ
/T1_2 1 Tf
[ ( g) -20 (ro) 40 (wth in hemol) 25 (ymph sho) 40 (w) 35 (ed that bacterial load increased o) 45 (v) 14.9 (er time in the) 10 ( ) ] TJ
0 Tw
0 -1.444 TD
(presence of dendrimers\056) Tj
/TT1 1 Tf
-0.005 Tc
0.005 Tw
T*
[ (Conclus) 0.6 (ion\072) ] TJ
/T1_2 1 Tf
-0.062 Tw
[ ( Ov) 14.8 (erall\054 our \037ndings indicated that dG3KL and dTNS18 peptide dendrimers sho) 39.8 (w) -5 ( ) ] TJ
0 Tc
0.037 Tw
0 -1.444 TD
[ (in vitro acti) 25.1 (vity comparab) 20 (le to ) 49.8 (T) 80 (ob ag) 5 (ainst both ) ] TJ
/T1_3 1 Tf
[ (P) 200 (\056 aeruginosa) ] TJ
/T1_2 1 Tf
( planktonic and bio\037lm cells at ) Tj
-0.032 Tw
0 -1.444 Td
[ (concentrations not to) 20 (xic in vi) 25 (v) 20 (o\056 Fur) -20 (ther studies are w) 25 (ar) -29.9 (ranted to e) 15 (xplore dif) 25 (ferent dosages and ) ] TJ
0.008 Tw
T*
[ (to increase the bioa) 35 (v) 25 (ailability of the peptides to solv) 15 (e the lack of protecti) 24.9 (v) 15 (e ef) 25 (fect obser) -20 (v) 15 (ed in ) ] TJ
/T1_3 1 Tf
0 Tw
0 -1.444 TD
[ (G) 25 (\056 mellonella) ] TJ
/T1_2 1 Tf
[ ( lar) -19.9 (v) 25 (ae\056) ] TJ
/TT1 1 Tf
0 -1.444 Td
[ (K) 59.8 (e) 15.4 (yw) 20.5 (or) 14.7 (ds\072) ] TJ
/T1_2 1 Tf
0.044 Tw
[ ( c) 15 (ystic \037brosis\054 chronic infection\054 ) ] TJ
/T1_3 1 Tf
(Pseudomonas aeruginosa) Tj
/T1_2 1 Tf
(\054 dendrimer peptides\054 ) Tj
0 Tw
T*
(bio\037lm) Tj
/TT1 1 Tf
14 0 0 14 221.15 155.7861 Tm
[ (Intr) 24.9 (oduction) ] TJ
/T1_2 1 Tf
0.054 Tw
10 0 0 10 221.15 141.7861 Tm
[ (CF patients are prone to chronic infection of the respirator) -19.9 (y tract\054 w) 20 (hich ultimatel) 25 (y ) ] TJ
0.104 Tw
0 -1.4 TD
[ (leads to pulmonar) -20 (y f) -10 (ailure\054 the primar) -20 (y cause of death in this patient population\056) ] TJ
0 Tw
5.83 0 0 5.83 555.235 131.1161 Tm
(1) Tj
10 0 0 10 558.15 127.7861 Tm
( ) Tj
/T1_3 1 Tf
0.005 Tc
0.125 Tw
-33.7 -1.4 Td
(Pseudomonas aeruginosa) Tj
/T1_2 1 Tf
[ ( is the most pre) 24.8 (v) 24.8 (alent respirator) -20.2 (y patho) 24.8 (gen in adult CF) 5 ( ) ] TJ
0 Tc
0 Tw
T*
[ (patients\054 w) 20 (here it is the main cause of morbidity and mor) -19.8 (tality) 85 (\056) ] TJ
5.83 0 0 5.83 471.3877 103.1161 Tm
(2) Tj
ET
q
1 0 0 1 70.85 180.5361 cm
0 0 m
136.1 0 l
S
Q
BT
/TT0 1 Tf
8 0 0 8 70.85 166.2861 Tm
(Correspondence\072 Arianna Pompilio) Tj
0 -1.187 TD
(Department of Medical\054 Oral and ) Tj
T*
(Biotechnological Sciences\054 G\056 d\222Annunzio ) Tj
T*
(University of Chieti\055Pescara\054 Via dei ) Tj
T*
(Vestini 31\054 66100 Chieti \050CH\051\054 Italy) Tj
T*
(Tel ) Tj
/T1_4 1 Tf
(\035) Tj
/TT0 1 Tf
(39 871 54 1519) Tj
T*
(Fax ) Tj
/T1_4 1 Tf
(\035) Tj
/TT0 1 Tf
(39 871 54 1520) Tj
T*
(Email arianna\056pompilio\100unich\056it) Tj
ET
q
0 0 612 792 re
W
n
BT
/T1_2 1 Tf
8 0 0 8 630 780.928 Tm
[ (Jour) -20 (nal name\072 Infection and Dr) -19.8 (ug Resistance ) ] TJ
0 -1.25 TD
[ (Ar) -20 (ticle Designation\072 ORIGIN) 35.2 (AL RESEARCH) ] TJ
T*
[ (Y) 160 (ear\072 2018) ] TJ
T*
[ (V) 129 (olume\072 11) ] TJ
T*
[ (Running head v) 15 (erso\072 P) 40.1 (ompilio et al) ] TJ
T*
[ (Running head recto\072 P) 40.1 (eptide dendrimers ag) 5.1 (ainst P) 160 (\056 aer) -20 (uginosa CF strains) ] TJ
T*
[ (DOI\072 http\072\057\057dx\056doi\056or) 18 (g\05710\0562147\057IDR\056S168868) ] TJ
ET
Q
Q
q
q
0.94074 0 0 0.94074 26 0 cm
/Xi0 Do
Q
Q
Q
endstream
endobj
24 0 obj
<<
/Metadata 25 0 R
>>
endobj
25 0 obj
<<
/Length 4034
/Type /Metadata
/Subtype /XML
>>
stream
application/postscript
Ripellino
published by Dove Press
antidepressants
major depressive disorder
cost-effectiveness quality of life
Italy
Pharmacoeconomic analysis of antidepressants in Italy
CEOR-52063-c-quality--cost-and-quality-of-life-pharmacoeconomic-analysi
Adobe Illustrator CS3
2013-12-18T16:41:36+05:30
2013-12-18T16:41:37+05:30
2013-12-18T16:41:37+05:30
uuid:056A2D29D567E311A407C7E9922C2CB0
uuid:066A2D29D567E311A407C7E9922C2CB0
uuid:6f43df80-ab6c-4265-b549-9c20b0dc1c29
adobe:docid:indd:84c20eb9-50eb-11e3-9222-8aeb07a88b07
proof:pdf
Print
False
1
False
False
612.000000
792.000000
Points
Cyan
Magenta
Yellow
Black
Default Swatch Group
0
endstream
endobj
26 0 obj
[ /Indexed 27 0 R 130 29 0 R ]
endobj
27 0 obj
[ /ICCBased 28 0 R ]
endobj
28 0 obj
<<
/Length 2574
/N 3
/Filter /FlateDecode
>>
stream
HyTSwoɞc
[5laQIBHADED2mtFOE.c}088GNg9w߽ '0 ֠Jb
2y.-;!KZ ^i"L0-
@8(r;q7Ly&Qq4j|9
V)gB0iW8#8wթ8_٥ʨQQj@&A)/g>'K t;\
ӥ$պFZUn(4T%)뫔0C&Zi8bxEB;Pӓ̹Aom?W=
x- [ 0}y)7ta>jT7@tܛ`q2ʀ&6ZLĄ?_yxg)˔zçLU*uSkSeO4?c. R
߁-25 S>ӣVd`rn~Y&+`;A4 A9 =-tl`;~p Gp| [`L`< "AYA+Cb(R, *T2B-
ꇆnQt}MA0alSx k&^>0|>_',G!"F$H:R!zFQd?r9\A&GrQhE]a4zBgE#H *B=0HIpp0MxJ$D1D, VĭKĻYdE"EI2EBGt4MzNr!YK ?%_(0J:EAiQ(()ӔWT6U@P+!~mDeԴ!hӦh/']B/ҏӿ?a0nhF!X8܌kc&5S6lIa2cKMA!E#ƒdV(kel
}}Cq9
N')].uJr
wG xR^[oƜchg`>b$*~ :Eb~,m,-ݖ,Y¬*6X[ݱF=3뭷Y~dó tizf6~`{v.Ng#{}}jc1X6fm;'_9 r:8q:˜O:ϸ8uJqnv=MmR 4
n3ܣkGݯz=[==<=GTB(/S,]6*-W:#7*e^YDY}UjAyT`#D="b{ų+ʯ:!kJ4Gmt}uC%K7YVfFY.=b?SƕƩȺy
چk5%4m7lqlioZlG+Zzmzy]?uuw|"űNwW&e֥ﺱ*|j5kyݭǯg^ykEklD_p߶7Dmo꿻1ml{Mś
nLl<9O [$h՛BdҞ@iءG&vVǥ8nRĩ7u\ЭD- u`ֲK³8%yhYѹJº;.!
zpg_XQKFAǿ=ȼ:ɹ8ʷ6˶5̵5͵6ζ7ϸ9к<Ѿ?DINU\dlvۀ܊ݖޢ)߯6DScs
2F[p(@Xr4Pm8Ww)Km
endstream
endobj
29 0 obj
<<
/Length 382
/Filter /FlateDecode
>>
stream
HM/` wϛjmg х6lSQ]H/‛%7?/>.OOhވE1xGs.Ң/iqZ$us)u)q!t%`⤒ T1t
L4 n C\5HjKT!j:TeUTTʴRVQY`H7*R%
,*Z$
3ZAY+ p-k )
endstream
endobj
30 0 obj
[ /Indexed 27 0 R 2 31 0 R ]
endobj
31 0 obj
<<
/Length 9
>>
stream
)
endstream
endobj
32 0 obj
[ /Indexed 27 0 R 2 33 0 R ]
endobj
33 0 obj
<<
/Length 9
>>
stream
m
endstream
endobj
34 0 obj
[ /Indexed 27 0 R 2 35 0 R ]
endobj
35 0 obj
<<
/Length 9
>>
stream
;Y
endstream
endobj
36 0 obj
<<
/Filter /FlateDecode
/BBox [ 0 792 612 0 ]
/Resources <<
/ColorSpace <<
/CS0 27 0 R
>>
/ExtGState <<
/GS0 37 0 R
>>
>>
/Length 90
/Matrix [ 1 0 0 1 0 0 ]
/Subtype /Form
>>
stream
Hw6PpV0 C`g?.=Sr_@{)pUs**Y*Z[*$rsL,`@. q
endstream
endobj
37 0 obj
<<
/AIS false
/BM /Normal
/CA 1
/OPM 0
/SMask /None
/ca 1
/Type /ExtGState
/OP true
/SA true
/op true
>>
endobj
38 0 obj
<<
/Filter /FlateDecode
/BBox [ 0 792 612 0 ]
/Resources <<
/ColorSpace <<
/CS0 27 0 R
>>
/ExtGState <<
/GS0 39 0 R
>>
/Font <<
/TT0 40 0 R
/T1_0 44 0 R
>>
/ProcSet [ /PDF /Text ]
>>
/Length 450
/Matrix [ 1 0 0 1 0 0 ]
/Subtype /Form
>>
stream
HlRMo0WhPұbo0p.b~?GQ~zC& jQ{)OLb;A'`x0$6džCy<>
Gئ4L~8_In#i؞}?p߾enY1h4z߉/m|U*]Ze4}+M/g:O~oeGkRE-<큿?y,UɲR2A䓌D]6*x_}V(*nʢkf^/6_z!ɢ_u1Zg̓XRX(3DT.
TΛJz[MVBv+)<1,'ϘwH+T&V? ?ɅQ Ikc;gkX$S~5T|i z̸Y
endstream
endobj
39 0 obj
<<
/AIS false
/BM /Normal
/CA 1
/OPM 1
/SMask /None
/ca 1
/Type /ExtGState
/OP false
/SA true
/op false
>>
endobj
40 0 obj
<<
/FirstChar 32
/Widths [ 278 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 667 0 0 0 0 469 0 0 0 0 0 0 0 0 823 0 0 0 0 604 0 0 0 0 0 0 0 0 0 0 0 0 0 0 438 0 479 0 0 0 219 0 0 219 0 500 0 500 0 396 385 333 500 0 0 500 ]
/Encoding /WinAnsiEncoding
/Type /Font
/BaseFont /YEYUNS+GillSansMT
/LastChar 120
/Subtype /TrueType
/FontDescriptor 41 0 R
/ToUnicode 43 0 R
>>
endobj
41 0 obj
<<
/FontBBox [ -162 -282 1041 918 ]
/FontName /YEYUNS+GillSansMT
/FontFile2 42 0 R
/Descent -282
/XHeight 449
/Flags 32
/FontStretch /Normal
/Ascent 918
/StemV 88
/Type /FontDescriptor
/FontFamily (Gill Sans MT)
/ItalicAngle 0
/FontWeight 400
/CapHeight 682
>>
endobj
42 0 obj
<<
/Length 13625
/Filter /FlateDecode
/Length1 19112
>>
stream
HtVkp>wʻhz",FZN$dǀ:\C cã*v8iJ0fB:7PahNt24mrڴO5{{9;߷ t Eկhe?T ^CƖDl3@~ؾ)ogY NsbUw!@] U6o ~ 1W64]$ *Ba/GI[6m9[S lߺ#13 SҰ%^ӄohY[%Z7ne.yb寗>AK13櫅x!ycA|Slmr sc),cLyX[t[m"&I5aj3zs{pZu
xhB~ֵt1tsED'^p:켷`r$*vK&??hs@;bx~y+b=W1 t