Retrospective validation of the laparoscopic ICG SLN mapping in patients with grade 3 endometrial cancer.

Papadia, Andrea; Gasparri, Maria Luisa; Radan, Anda-Petronela; Stämpfli, Chantal A L; Rau, Tilman; Mueller, Michael D (2018). Retrospective validation of the laparoscopic ICG SLN mapping in patients with grade 3 endometrial cancer. Journal of cancer research and clinical oncology, 144(7), pp. 1385-1393. Springer 10.1007/s00432-018-2648-y

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PURPOSE To evaluate the sensitivity, negative predictive value (NPV) and false-negative (FN) rate of the near infrared (NIR) indocyanine green (ICG) sentinel lymph node (SLN) mapping in patients with poorly differentiated endometrial cancer who have undergone a full pelvic and para-aortic lymphadenectomy after SLN mapping. METHODS We performed a retrospective analysis of patients with endometrial cancer undergoing a laparoscopic NIR-ICG SLN mapping followed by a systematic pelvic and para-aortic lymphadenectomy. Inclusion criteria were a grade 3 endometrial cancer or a high-risk histology (papillary serous, clear cell carcinoma, carcinosarcoma, and neuroendocrine carcinoma) and a completion pelvic and para-aortic lymphadenectomy to the renal vessels after SLN mapping. Overall and bilateral detection rates, sensitivity, NPV, and FN rates were calculated. RESULTS From December 2012 until January 2017, 42 patients fulfilled inclusion criteria. Overall and bilateral detection rates were 100 and 90.5%, respectively. Overall, 23.8% of the patients had lymph node metastases. In one patient, despite negative bilateral pelvic SLNs, a metastatic non-SLN-isolated para-aortic metastasis was detected. This NSLN was clinically suspicious and sent to frozen section analysis during the surgery. FN rate, sensitivity, and NPV were 10, 90, and 97.1%, respectively. For the SLN mapping algorithm, FN rate, sensitivity, and NPV were 0, 100, and 100%, respectively. CONCLUSIONS Laparoscopic NIR-ICG SLN mapping in high-risk endometrial cancer patients has acceptable sensitivity, FN rate, and NPV.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology
04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology

UniBE Contributor:

Papadia, Andrea; Radan, Anda-Petronela; Rau, Tilman and Mueller, Michael


600 Technology > 610 Medicine & health








Tilman Rau

Date Deposited:

30 Jan 2019 08:15

Last Modified:

03 Nov 2019 19:23

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Carcinosarcomas Clear cell carcinoma Endometrial cancer Grade 3 Sentinel lymph node biopsy Uterine papillary serous carcinoma




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