Cage-induced stereotypies in female ICR CD-1 mice do not correlate with recurrent perseveration

Gross, A N; Engel, A K; Richter, S H; Garner, J P; Würbel, Hanno (2011). Cage-induced stereotypies in female ICR CD-1 mice do not correlate with recurrent perseveration. Behavioural brain research, 216(2), pp. 613-20. Amsterdam: Elsevier 10.1016/j.bbr.2010.09.003

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Stereotypies are repetitive, unvarying, apparently purposeless behavioural patterns. They develop in animals kept in barren environments and are highly prevalent in laboratory mice (Mus musculus), yet their underlying mechanisms have remained elusive. In humans, stereotypies are associated with several psychiatric disorders and are thought to reflect dysfunction of inhibition of motor programs mediated by the corticostriatal circuitry, resulting in recurrent perseveration (=inappropriate repetition of behavioural responses). Several studies in captive animals of different species have reported a correlation between stereotypy performance and perseverative behaviour, indicating a similar dysfunction. To examine whether stereotypies in mice correlate with recurrent perseveration and whether they are causally related, we raised 40 female ICR CD-1 mice in either barren or enriched cages from three to either six or 16 weeks of age (2 x 2 factorial design) and assessed stereotypic behaviour in the home cage and recurrent perseveration on a two-choice guessing task. Enrichment significantly reduced stereotypic behaviour both at six and 16 weeks of age and recurrent perseveration increased with age. Although enriched housing reduced the number of repetitions in the guessing task significantly, there was no clear evidence for an effect on recurrent perseveration, and recurrent perseveration did not correlate positively with stereotypy level. These findings indicate either that this test did not measure recurrent perseveration or that cage stereotypies in these mice do not reflect behavioural disinhibition as measured by recurrent perseveration.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Public Health Institute > Animal Welfare Division

UniBE Contributor:

Würbel, Hanno

ISSN:

0166-4328

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:32

Last Modified:

28 Feb 2014 08:39

Publisher DOI:

10.1016/j.bbr.2010.09.003

Web of Science ID:

000285217300017

URI:

https://boris.unibe.ch/id/eprint/12289 (FactScience: 218605)

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