A vaccine against Alzheimer's disease: anything left but faith?

Bachmann, Martin F; Jennings, Gary T; Vogel, Monique; Bachmann, Martin; Vogel, Monique (2019). A vaccine against Alzheimer's disease: anything left but faith? Expert opinion on biological therapy, 19(1), pp. 73-78. Taylor & Francis Group 10.1080/14712598.2019.1554646

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INTRODUCTION Alzheimer's disease looms as a profound and growing threat to future human health. The disease is thought to be primarily driven by aberrant proteolysis of the amyloid precursor protein and amyloid beta (Aβ) plaque deposition. Areas covered: We provide an overview of the molecular pathology that leads to an increase in Aβ peptide accumulation, of the mechanism of action for antibody mediated therapies and of the therapeutic vaccines that target Aβ under development. We also discuss the rationale for using vaccines in the early stages of the disease. Expert opinion: The major components of β-amyloid plaques are Aβ and Aβ peptides derived from the Amyloid precursor protein (APP). Reducing these plaques by means of passive or active vaccination against Aβ-peptides has been a long-running endeavour but with disappointing results as the impact on disease progression has been minimal. The data gathered to date could suggest that antibodies do not work, mainly because the studies have not been performed in an optimal fashion. The emerging views are that patients should be treated earlier, ideally in the prodromal or symptom free stage, antibody levels have to be high and the correct epitope must be targeted. More clinical trials to fully explore the potential of vaccines are therefore warranted.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology

UniBE Contributor:

Bachmann, Martin and Vogel, Monique

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1744-7682

Publisher:

Taylor & Francis Group

Language:

English

Submitter:

Valery Beer

Date Deposited:

23 Jan 2019 16:56

Last Modified:

23 Jan 2019 16:56

Publisher DOI:

10.1080/14712598.2019.1554646

PubMed ID:

30526133

Uncontrolled Keywords:

Abeta1-42 Abeta3-6 Alzeimer`s vaccine virus like particle

URI:

https://boris.unibe.ch/id/eprint/122893

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