Modified resin infiltration of non-, micro- and cavitated proximal caries lesions in vitro

Askar, H; Schwendicke, F; Lausch, J; Meyer-Lückel, Hendrik; Paris, S (2018). Modified resin infiltration of non-, micro- and cavitated proximal caries lesions in vitro. Journal of dentistry, 74, pp. 56-60. Elsevier Science 10.1016/j.jdent.2018.03.010

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OBJECTIVE Infiltrant resin (IR) is currently indicated for non-cavitated caries lesions. However, modifying the technique might expand its indication spectrum to micro-cavitated lesions. The present study aimed to evaluate the penetration/filling ability of a newly developed micro-filled infiltrant resin (MFIR) in non-, micro- and cavitated natural caries lesions. MATERIALS AND METHODS Proximal lesions in 120 extracted human teeth with ICDAS-2 (n = 30), 3 (n = 45) and 5 (n = 45) lesions were etched with 15% hydrochloric acid gel for 2 min and allocated to one of the following treatments; IR: lesions (ICDAS-2, 3 and 5; each n = 15) were treated with commercial infiltrant resin for 3 min. MFIR: experimental MFIR [55 wt% IR plus 45 wt% organic fillers] was applied to lesions (ICDAS-2, 3 and 5; each n = 15) for 3 min. IR + FC: IR was applied for 3 min, light-cured, and cavities (ICDAS-3 and 5; each n = 15) filled with flowable composite (FC). Percentage infiltration of the demineralized enamel (Inf.%) and percentage filling of the cavity (Fill.%) were analyzed using dual-fluorescence staining and confocal microscopy. RESULTS No significant differences in Inf.% (range of medians: 57%-100%) were observed between different treatments (p > 0.05; Kruskal-Wallis) within each ICDAS-code. Fill.% of cavities was significantly higher in groups MFIR (median in ICDAS-3/-5: 100%/100%) and IR + FC (100%/100%) than IR (25%/38%) (p < 0.05). CONCLUSION MFIR showed similar penetration into natural lesions as the commercial infiltrant, but better ability to fill cavitated areas. CLINICAL RELEVANCE MFIR and IR + FC might provide a new micro-invasive treatment for small cavitated proximal lesions.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > School of Dental Medicine > Department of Preventive, Restorative and Pediatric Dentistry

UniBE Contributor:

Meyer-Lückel, Hendrik


600 Technology > 610 Medicine & health




Elsevier Science




Hendrik Meyer-Lückel

Date Deposited:

21 Feb 2019 16:12

Last Modified:

27 Oct 2019 02:02

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Caries infiltration Cavitation Enamel lesions ICDAS Infiltrant Micro-filled infiltrant resin




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