Hepatic microcirculation and mechanisms of portal hypertension.

Gracia Sancho, Jorge Sergio; Marrone, Giusi; Fernández-Iglesias, Anabel (2019). Hepatic microcirculation and mechanisms of portal hypertension. Nature reviews - gastroenterology & hepatology, 16(4), pp. 221-234. Nature Publishing Group 10.1038/s41575-018-0097-3

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The liver microcirculatory milieu, mainly composed of liver sinusoidal endothelial cells (LSECs), hepatic stellate cells (HSCs) and hepatic macrophages, has an essential role in liver homeostasis, including in preserving hepatocyte function, regulating the vascular tone and controlling inflammation. Liver microcirculatory dysfunction is one of the key mechanisms that promotes the progression of chronic liver disease (also termed cirrhosis) and the development of its major clinical complication, portal hypertension. In the present Review, we describe the current knowledge of liver microcirculatory dysfunction in cirrhotic portal hypertension and appraise the preclinical models used to study the liver circulation. We also provide a comprehensive summary of the promising therapeutic options to target the liver microvasculature in cirrhosis.

Item Type:	Journal Article (Review Article)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
UniBE Contributor:	Gracia Sancho, Jorge Sergio
Subjects:	600 Technology > 610 Medicine & health
ISSN:	1759-5045
Publisher:	Nature Publishing Group
Language:	English
Submitter:	Thi Thao Anh Pham
Date Deposited:	04 Feb 2019 08:01
Last Modified:	05 Dec 2022 15:23
Publisher DOI:	10.1038/s41575-018-0097-3
PubMed ID:	30568278
URI:	https://boris.unibe.ch/id/eprint/122959