Gut Microbiota and Iron: The Crucial Actors in Health and Disease.

Yilmaz, Bahtiyar; Li, Hai (2018). Gut Microbiota and Iron: The Crucial Actors in Health and Disease. Pharmaceuticals, 11(4) MDPI 10.3390/ph11040098

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Iron (Fe) is a highly ample metal on planet earth (~35% of the Earth's mass) and is particularly essential for most life forms, including from bacteria to mammals. Nonetheless, iron deficiency is highly prevalent in developing countries, and oral administration of this metal is so far the most effective treatment for human beings. Notably, the excessive amount of unabsorbed iron leave unappreciated side effects at the highly interactive host⁻microbe interface of the human gastrointestinal tract. Recent advances in elucidating the molecular basis of interactions between iron and gut microbiota shed new light(s) on the health and pathogenesis of intestinal inflammatory diseases. We here aim to present the dynamic modulation of intestinal microbiota by iron availability, and conversely, the influence on dietary iron absorption in the gut. The central part of this review is intended to summarize our current understanding about the effects of luminal iron on host⁻microbe interactions in the context of human health and disease.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

UniBE Contributor:

Yilmaz, Bahtiyar and Li, Hai

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1424-8247

Publisher:

MDPI

Language:

English

Submitter:

Thi Thao Anh Pham

Date Deposited:

04 Feb 2019 09:28

Last Modified:

04 Feb 2019 09:28

Publisher DOI:

10.3390/ph11040098

PubMed ID:

30301142

Uncontrolled Keywords:

SCFA colorectal cancer gut microbiota inflammatory bowel disease (IBD) intestinal inflammation iron iron supplementation iron transporters mucosal immunity

BORIS DOI:

10.7892/boris.122994

URI:

https://boris.unibe.ch/id/eprint/122994

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