Retrospective comparison of maternal vs. HPA-matched donor platelets for treatment of fetal alloimmune thrombocytopenia

Giers, G; Wenzel, F; Fischer, J; Stockschläder, M; Riethmacher, R; Lorenz, H; Tutschek, B (2010). Retrospective comparison of maternal vs. HPA-matched donor platelets for treatment of fetal alloimmune thrombocytopenia. Vox sanguinis, 98(3 Pt 2), pp. 423-30. Oxford: Wiley-Blackwell 10.1111/j.1423-0410.2009.01268.x

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In fetal alloimmune thrombocytopenia (FAIT), transplacental maternal antibodies cause destruction of fetal platelets. FAIT is similar to fetal Rhesus haemolytic disease, but half of the affected fetuses are born to primiparous women. In 10-20% of cases, prenatal and perinatal intracranial haemorrhages are reported. Different therapeutic approaches have been described, including maternally administered high-dose intravenous immunoglobulin (high dose IVIG) without or with steroids or intrauterine transfusion (IUT) of compatible platelets. For the latter, the use of plasma-free maternal and donor platelets has been described, but a comparison of these two sources of platelets has not been reported.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Tutschek, Boris

ISSN:

0042-9007

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:07

Last Modified:

06 Dec 2013 13:19

Publisher DOI:

10.1111/j.1423-0410.2009.01268.x

PubMed ID:

19874573

Web of Science ID:

000275530800005

URI:

https://boris.unibe.ch/id/eprint/123 (FactScience: 196228)

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