Oncogene addiction as a foundation of targeted cancer therapy: The paradigm of the MET receptor tyrosine kinase.

Orlando, Eleonora; Aebersold, Daniel; Medova, Michaela; Zimmer, Yitzhak (2019). Oncogene addiction as a foundation of targeted cancer therapy: The paradigm of the MET receptor tyrosine kinase. Cancer letters, 443, pp. 189-202. Elsevier 10.1016/j.canlet.2018.12.001

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Following nearly two decades of its conception, the phenomenon of oncogene addiction still represents a key concept of how progresses in basic research can translate to unprecedented translational breakthroughs. Coined by Bernard Weinstein, this term refers to the phenomenon by which cancer cells can exhibit dependence on a single oncogenic protein or signaling pathway for sustaining proliferation and survival, despite the wide burden of genetic lesions characterizing their genomic background, revealing thus a promising Achilles' heel of cancer. Importantly, this concept aided the design and clinical implementation of molecularly targeted anticancer therapies, further supporting the paradigm shift witnessed in clinical oncology towards an individual-based, personalized era. In this review, we outline the path of discovery concerning the oncogene addiction concept and focus on the MET receptor tyrosine kinase as a model addicting oncoprotein to further explore potential and pitfalls stemming from the implementation of anticancer strategies targeting tumor dependencies beyond their blending with other therapeutic opportunities.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Radio-Onkologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Radio-Onkologie

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Orlando, Eleonora; Aebersold, Daniel; Medova, Michaela and Zimmer, Yitzhak

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0304-3835

Publisher:

Elsevier

Language:

English

Submitter:

Beatrice Scheidegger

Date Deposited:

29 Jan 2019 11:20

Last Modified:

23 Oct 2019 02:23

Publisher DOI:

10.1016/j.canlet.2018.12.001

PubMed ID:

30550851

Uncontrolled Keywords:

DNA damage response Immunotherapy MET Oncogene addiction Receptor tyrosine kinases Targeted anticancer therapy

BORIS DOI:

10.7892/boris.123012

URI:

https://boris.unibe.ch/id/eprint/123012

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