Biodistribution, Clearance, and Long-Term Fate of Clinically Relevant Nanomaterials.

Bourquin, Joël; Milosevic, Ana; Hauser, Daniel; Lehner, Roman; Blank, Fabian; Petri-Fink, Alke; Rothen-Rutishauser, Barbara (2018). Biodistribution, Clearance, and Long-Term Fate of Clinically Relevant Nanomaterials. Advanced materials, 30(19), e1704307. Wiley-VCH 10.1002/adma.201704307

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Realization of the immense potential of nanomaterials for biomedical applications will require a thorough understanding of how they interact with cells, tissues, and organs. There is evidence that, depending on their physicochemical properties and subsequent interactions, nanomaterials are indeed taken up by cells. However, the subsequent release and/or intracellular degradation of the materials, transfer to other cells, and/or translocation across tissue barriers are still poorly understood. The involvement of these cellular clearance mechanisms strongly influences the long-term fate of used nanomaterials, especially if one also considers repeated exposure. Several nanomaterials, such as liposomes and iron oxide, gold, or silica nanoparticles, are already approved by the American Food and Drug Administration for clinical trials; however, there is still a huge gap of knowledge concerning their fate in the body. Herein, clinically relevant nanomaterials, their possible modes of exposure, as well as the biological barriers they must overcome to be effective are reviewed. Furthermore, the biodistribution and kinetics of nanomaterials and their modes of clearance are discussed, knowledge of the long-term fates of a selection of nanomaterials is summarized, and the critical points that must be considered for future research are addressed.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Pneumologie (Erwachsene)
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology

UniBE Contributor:

Blank, Fabian


600 Technology > 610 Medicine & health








Rahel Holderegger

Date Deposited:

04 Feb 2019 18:27

Last Modified:

20 Dec 2019 13:51

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PubMed ID:


Uncontrolled Keywords:

biodistribution clearance long-term fate nanomaterials routes of exposure




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