Multicentre observational screening survey for the detection of CTEPH following pulmonary embolism.

Coquoz, Nicolas; Weilenmann, Daniel; Stolz, Daiana; Popov, Vladimir; Azzola, Andrea; Fellrath, Jean-Marc; Stricker, Hans; Pagnamenta, Alberto; Ott, Sebastian; Ulrich, Silvia; Györik, Sandor; Pasquier, Jérôme; Aubert, John-David (2018). Multicentre observational screening survey for the detection of CTEPH following pulmonary embolism. European respiratory journal, 51(4) European Respiratory Society 10.1183/13993003.02505-2017

[img] Text
1702505.full.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (444kB) | Request a copy

Chronic thromboembolic pulmonary hypertension (CTEPH) is a severe complication of pulmonary embolism. Its incidence following pulmonary embolism is debated. Active screening for CTEPH in patients with acute pulmonary embolism is yet to be recommended.This prospective, multicentre, observational study (Multicentre Observational Screening Survey for the Detection of Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Following Pulmonary Embolism (INPUT on PE); ISRCTN61417303) included patients with acute pulmonary embolism from 11 centres in Switzerland from March 2009 to November 2016. Screening for possible CTEPH was performed at 6, 12 and 24 months using a stepwise algorithm that included a dyspnoea phone-based survey, transthoracic echocardiography, right heart catheterisation and radiological confirmation of CTEPH.Out of 1699 patients with pulmonary embolism, 508 patients were assessed for CTEPH screening over 2 years. CTEPH incidence following pulmonary embolism was 3.7 per 1000 patient-years, with a 2-year cumulative incidence of 0.79%. The Swiss pulmonary hypertension registry consulted in December 2016 did not report additional CTEPH cases in these patients. The survey yielded 100% sensitivity and 81.6% specificity. The second step echocardiography in newly dyspnoeic patients showed a negative predictive value of 100%.CTEPH is a rare but treatable disease. A simple and sensitive way for CTEPH screening in patients with acute pulmonary embolism is recommended.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Azzola, Andrea; Stricker, Hans and Ott, Sebastian Robert


600 Technology > 610 Medicine & health




European Respiratory Society




Rahel Holderegger

Date Deposited:

21 Jan 2019 13:24

Last Modified:

11 Nov 2019 00:33

Publisher DOI:


PubMed ID:





Actions (login required)

Edit item Edit item
Provide Feedback