Neuroendocrine Liver Metastasis-a Specific Set of Markers to Detect Primary Tumor Sites.

Selberherr, Andreas; Koperek, Oskar; Riss, Philipp; Scheuba, Christian; Kaderli, Reto; Perren, Aurel; Niederle, Bruno (2019). Neuroendocrine Liver Metastasis-a Specific Set of Markers to Detect Primary Tumor Sites. Endocrine pathology, 30(1), pp. 31-34. Springer 10.1007/s12022-018-9558-z

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The diagnosis of neuroendocrine neoplasia (NEN) is often made at an advanced stage of disease, including hepatic metastasis. At this point, the primary may still be unknown and sometimes cannot even be detected by functional imaging, especially in very small tumors of the pancreas (pan) and small intestinal (si) entities. The site of the primary may be based on biopsy specimens of the liver applying a specific set of markers. Specimens of liver metastases from 87 patients with NENs were studied. In retrospect, 50 patients had si and 37 pan NENs. Tissue samples were evaluated by immunohistochemistry. The markers applied were insulin gene enhancer protein Islet-1 (ISL-1), homeobox protein CDX-2 (CDX2), thyroid transcription factor 1 (TTF-1), and serotonin. Positive stains for CDX2 were documented in 43 (86%) and for serotonin in 45 (90%) of 50 siNENs. Three panNENs were positive for CDX2 and one for serotonin, respectively. ISL-1 was negative throughout in siNENs and also negative in 8 of 50 panNENs (21.6%). TTF-1 was negative in more than 90% of the specimens of either entity. Immunohistochemical markers in liver metastasis can lead the way to the site of the primary NEN. They should always be used in combined clusters.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Kaderli, Reto Martin and Perren, Aurel

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1559-0097

Publisher:

Springer

Language:

English

Submitter:

Aurel Perren

Date Deposited:

04 Feb 2019 18:40

Last Modified:

23 Jan 2020 14:52

Publisher DOI:

10.1007/s12022-018-9558-z

PubMed ID:

30456697

Uncontrolled Keywords:

CDX2 Islet 1 Liver metastasis Neuroendocrine neoplasia Serotonin

BORIS DOI:

10.7892/boris.123051

URI:

https://boris.unibe.ch/id/eprint/123051

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