Systematic Review of In Vivo Animal Models of Subarachnoid Hemorrhage: Species, Standard Parameters, and Outcomes.

Marbacher, Serge; Grüter, Basil; Schöpf, Salome; Croci, Davide; Nevzati, Edin; D'Alonzo, Donato; Lattmann, Jacqueline; Roth, Tabitha; Bircher, Benjamin; Wolfert, Christina; Muroi, Carl; Dutilh, Gilles; Widmer, Hans Rudolf; Fandino, Javier (2018). Systematic Review of In Vivo Animal Models of Subarachnoid Hemorrhage: Species, Standard Parameters, and Outcomes. Translational stroke research Springer 10.1007/s12975-018-0657-4

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In preclinical models, modification of experimental parameters associated with techniques of inducing subarachnoid hemorrhage (SAH) can greatly affect outcomes. To analyze how parameter choice affects the relevance and comparability of findings, we systematically reviewed 765 experimental studies of in vivo animal SAH models (2000-2014). During the last decade, we found marked increases in publications using smaller species and models for simulating acute events after SAH. Overall, the fewer types of species and models used did not correlate with an increased standardization in the experimental characteristics and procedures. However, by species, commonly applied, reliable parameters for each experimental SAH technique were identified in mouse, rat, rabbit, and dog models. Our findings can serve as a starting point for discussion toward a more uniform performance of SAH experiments, development of preclinical SAH common data elements, and establishment of standardized protocols for multicenter preclinical trials.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery

UniBE Contributor:

Widmer, Hans Rudolf


600 Technology > 610 Medicine & health








Nicole Söll

Date Deposited:

04 Feb 2019 19:16

Last Modified:

12 May 2022 15:31

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Animal Delayed cerebral vasospasm Early brain injury Model Subarachnoid hemorrhage




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