Combination of cell transplantation and glial cell line-derived neurotrophic factor-secreting encapsulated cells in Parkinson's disease.

Widmer, Hans Rudolf (2018). Combination of cell transplantation and glial cell line-derived neurotrophic factor-secreting encapsulated cells in Parkinson's disease. Brain circulation, 4(3), pp. 114-117. Medknow 10.4103/bc.bc_19_18

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A major limitation of cell transplantation for Parkinson's disease (PD) is the mediocre survival of the grafted cells. Facilitating graft survival may improve the functional outcomes of the transplanted cells. Here, we discuss our observations that combination of rat fetal ventral mesencephalic (VM) tissue and encapsulated cells that secrete glial cell line-derived neurotrophic factor (GDNF) enhanced graft function in an animal model of PD. We described significant 2-fold increase in the number of tyrosine hydroxylase immunoreactive (TH-ir) cells per graft, as well as 1.7-fold and 9-fold increments in TH-ir fiber outgrowth into the host brain and toward the capsule with combined transplants and GDNF capsules as opposed to the VM transplants and mock-capsule group. These findings demonstrate that encapsulated GDNF-secreting cells improve graft survival that may optimize functional benefits for the treatment of PD.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery

UniBE Contributor:

Widmer, Hans Rudolf

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2455-4626

Publisher:

Medknow

Language:

English

Submitter:

Nicole Söll

Date Deposited:

08 Jan 2019 15:06

Last Modified:

23 Oct 2019 21:30

Publisher DOI:

10.4103/bc.bc_19_18

PubMed ID:

30450417

Uncontrolled Keywords:

Dopamine neurodegeneration neurotrophic factor stem cells transplantation

BORIS DOI:

10.7892/boris.123059

URI:

https://boris.unibe.ch/id/eprint/123059

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