Cytokine profiles of phakic and pseudophakic eyes with primary retinal detachment.

Garweg, Justus G; Zandi, Souska; Pfister, Isabel; Rieben, Robert; Skowronska, Magdalena; Tappeiner, Christoph (2019). Cytokine profiles of phakic and pseudophakic eyes with primary retinal detachment. Acta ophthalmologica, 97(4), e580-e588. Wiley 10.1111/aos.13998

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PURPOSE To compare the cytokine profiles of phakic (p) and pseudophakic (ps) eyes with primary rhegmatogenous retinal detachment (RD) to eyes with macular holes (MH) and to identify differences in the specific cytokine profiles. METHODS Aqueous humour (AH) and vitreous fluid (VF) were obtained from patients with primary RD without proliferative vitreoretinopathy undergoing vitrectomy. AH and VF of patients with macular holes (MH) served as controls. Forty-three different cytokines were quantified using multiplex cytokine analysis. Intergroup and intragroup comparisons were performed. To control for multiple comparisons, Holm's correction was applied. RESULTS VF and AH samples of 71 eyes with RD (pRD N = 38; psRD N = 33) and 26 eyes with MH were included. Cytokine levels in psRD and pRD were similar (none with >10-fold difference). The levels of 39 of 43 cytokines in the VF were significantly higher in eyes with RD than in those with MH (>10-fold: CXLC5, CCL26, CCL1, IL-6, CXCL11, CCL7, CCL13, MIG/CXCL9, CCL19 and TGF-β1). In the AH, 23 of 43 cytokines were significantly higher compared to MH (>10-fold: CXCL5, IL-4, IL-6, IL-8/CXCL8 and CCL7). CONCLUSION A complex, but nonspecific cytokine environmental response seems to initiate immunological and profibrotic processes following RD. Relevant differences in the cytokine profiles of eyes with pRD and psRD were not identified, whereas cytokine differences between AH and VF in RD could be explained by upregulation in the vitreous, a higher turn around in the anterior chamber, or differences in inflammatory cascades in both compartments.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Herz und Gefässe
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Augenklinik > Forschungsgruppe Augenheilkunde

UniBE Contributor:

Rieben, Robert and Tappeiner, Christoph

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1755-3768

Publisher:

Wiley

Language:

English

Submitter:

Christoph Tappeiner

Date Deposited:

01 Feb 2019 11:22

Last Modified:

25 Oct 2019 06:07

Publisher DOI:

10.1111/aos.13998

PubMed ID:

30561135

Uncontrolled Keywords:

biomarkers chemokines cytokines interleukins macular hole rhegmatogenous retinal detachment

BORIS DOI:

10.7892/boris.123073

URI:

https://boris.unibe.ch/id/eprint/123073

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