Height-specific blood pressure cutoffs for screening elevated and high blood pressure in children and adolescents: an International Study.

Hou, Yaping; Bovet, Pascal; Kelishadi, Roya; Litwin, Mieczysław; Khadilkar, Anuradha; Hong, Young Mi; Nawarycz, Tadeusz; Stawińska-Witoszyńska, Barbara; Aounallah-Skhiri, Hajer; Motlagh, Mohammad Esmaeil; Kim, Hae Soon; Khadilkar, Vaman; Krzyżaniak, Alicja; Ben Romdhane, Habiba; Heshmat, Ramin; Chiplonkar, Shashi; Krzywińska-Wiewiorowska, Małgorzata; Ati, Jalila El; Qorbani, Mostafa; Kajale, Neha; ... (2019). Height-specific blood pressure cutoffs for screening elevated and high blood pressure in children and adolescents: an International Study. Hypertension research, 42(6), pp. 845-851. Nature Publishing Group 10.1038/s41440-018-0178-2

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Pediatric blood pressure (BP) reference tables are generally based on sex, age, and height and tend to be cumbersome to use in routine clinical practice. In this study, we aimed to develop a new, height-specific simple BP table according to the international child BP reference table based on sex, age and height and to evaluate its performance using international data. We validated the simple table in a derivation cohort that included 58,899 children and adolescents aged 6-17 years from surveys in 7 countries (China, India, Iran, Korea, Poland, Tunisia, and the United States) and in a validation cohort that included 70,072 participants from three other surveys (China, Poland and Seychelles). The BP cutoff values for the simple table were calculated for eight height categories for both the 90th ("elevated BP") and 95th ("high BP") percentiles of BP. The simple table had a high performance to predict high BP compared to the reference table, with high values (boys/girls) of area under the curve (0.94/0.91), sensitivity (88.5%/82.9%), specificity (99.3%/99.7%), positive predictive values (93.9%/97.3%), and negative predictive values (98.5%/97.8%) in the pooled data from 10 studies. The simple table performed similarly well for predicting elevated BP. A simple table based on height only predicts elevated BP and high BP in children and adolescents nearly as well as the international table based on sex, age, and height. This has important implications for simplifying the detection of pediatric high BP in clinical practice.

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