Acute Liver Failure: From Textbook to Emergency Room and Intensive Care Unit With Concomitant Established and Modern Novel Therapies.

Doulberis, Michael; Kotronis, Georgios; Gialamprinou, Dimitra; Özgüler, Onur; Exadaktylos, Aristomenis; Oikonomou, Vasileios; Katsinelos, Panagiotis; Romiopoulos, Iordanis; Polyzos, Stergios A; Tzivras, Dimitri; Deretzi, Georgia; Dardiotis, Efthimios; Kountouras, Jannis (2019). Acute Liver Failure: From Textbook to Emergency Room and Intensive Care Unit With Concomitant Established and Modern Novel Therapies. Journal of clinical gastroenterology, 53(2), pp. 89-101. Wolters Kluwer 10.1097/MCG.0000000000001162

Doulberis, J Clin Gastroenterol 2019.pdf - Published Version
Available under License Publisher holds Copyright.

Download (356kB) | Preview

Acute liver failure is a rare hepatic emergent situation that affects primarily young people and has often a catastrophic or even fatal outcome. Definition of acute liver failure has not reached a universal consensus and the interval between the appearance of jaundice and hepatic encephalopathy for the establishment of the acute failure is a matter of debate. Among the wide variety of causes, acetaminophen intoxication in western societies and viral hepatitis in the developing countries rank at the top of the etiology list. Identification of the clinical appearance and initial management for the stabilization of the patient are of vital significance. Further advanced therapies, that require intensive care unit, should be offered. The hallmark of treatment for selected patients can be orthotopic liver transplantation. Apart from well-established treatments, novel therapies like hepatocyte or stem cell transplantation, additional new therapeutic strategies targeting acetaminophen intoxication and/or hepatic encephalopathy are mainly experimental, and some of them do not belong, yet, to clinical practice. For clinicians, it is substantial to have the alertness to timely identify the patient and transfer them to a specialized center, where more treatment opportunities are available.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > University Emergency Center
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine

UniBE Contributor:

Doulberis, Michael; Exadaktylos, Aristomenis and Oikonomou, Vasileios


600 Technology > 610 Medicine & health




Wolters Kluwer




Tobias Tritschler

Date Deposited:

05 Feb 2019 12:51

Last Modified:

07 Sep 2021 17:17

Publisher DOI:


PubMed ID:





Actions (login required)

Edit item Edit item
Provide Feedback