Potential impact of Helicobacter pylori-related metabolic syndrome on upper and lower gastrointestinal tract oncogenesis.

Kountouras, Jannis; Polyzos, Stergios A; Doulberis, Michael; Zeglinas, Christos; Artemaki, Fotini; Vardaka, Elizabeth; Deretzi, Georgia; Giartza-Taxidou, Evaggelia; Tzivras, Dimitri; Vlachaki, Efthymia; Kazakos, Evangelos; Katsinelos, Panagiotis; Mantzoros, Christos S (2018). Potential impact of Helicobacter pylori-related metabolic syndrome on upper and lower gastrointestinal tract oncogenesis. Metabolism : clinical and experimental, 87, pp. 18-24. Elsevier 10.1016/j.metabol.2018.06.008

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Both Helicobacter pylori infection and metabolic syndrome present significant global public health burdens. Metabolic syndrome is closely related to insulin resistance, the major underlying mechanism responsible for metabolic abnormalities, and Helicobacter pylori infection has been proposed to be a contributing factor. There is growing evidence for a potential association between Helicobacter pylori infection and insulin resistance, metabolic syndrome and related morbidity, including abdominal obesity, type 2 diabetes mellitus, dyslipidemia, hypertension, all of which increase mortality related to cardio-cerebrovascular disease, neurodegenerative disorders, nonalcoholic fatty liver disease and malignancies. More specifically, insulin resistance, metabolic syndrome and hyperinsulinemia have been associated with upper and lower gastrointestinal tract oncogenesis. Apart from cardio-cerebrovascular, degenerative diseases and nonalcoholic fatty liver disease, a number of studies claim that Helicobacter pylori infection is implicated in metabolic syndrome-related Barrett's esophagus and esophageal adenocarcinoma development, gastric and duodenal ulcers and gastric oncogenesis as well as lower gastrointestinal tract oncogenesis. This review summarizes evidence on the potential impact of Helicobacter pylori-related metabolic syndrome on gastroesophageal reflux disease-Barrett's esophagus-esophageal adenocarcinoma, gastric atrophy-intestinal metaplasia-dysplasia-gastric cancer and colorectal adenoma-dysplasia-colorectal cancer sequences. Helicobacter pylori eradication might inhibit these oncogenic processes, and thus further studies are warranted.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine

UniBE Contributor:

Doulberis, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1532-8600

Publisher:

Elsevier

Language:

English

Submitter:

Tobias Tritschler

Date Deposited:

07 Feb 2019 16:19

Last Modified:

05 Dec 2022 15:24

Publisher DOI:

10.1016/j.metabol.2018.06.008

PubMed ID:

29936174

BORIS DOI:

10.7892/boris.123181

URI:

https://boris.unibe.ch/id/eprint/123181

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