Noggin levels in nonalcoholic fatty liver disease: the effect of vitamin E treatment.

Polyzos, Stergios A; Kountouras, Jannis; Anastasilakis, Athanasios D; Makras, Polyzois; Hawa, Gerhard; Sonnleitner, Linda; Missbichler, Albert; Doulberis, Michael; Katsinelos, Panagiotis; Terpos, Evangelos (2018). Noggin levels in nonalcoholic fatty liver disease: the effect of vitamin E treatment. Hormones, 17(4), pp. 573-579. Springer 10.1007/s42000-018-0083-8

[img] Text
Polyzos-2018-Noggin levels in nonalcoholic fat.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (492kB)

AIM

The evaluation of (a) noggin levels in patients with simple steatosis (SS) vs. nonalcoholic steatohepatitis (NASH) vs. controls, and (b) the effect of combined spironolactone plus vitamin E vs. vitamin E monotherapy on noggin levels in biopsy-proven patients with nonalcoholic fatty liver disease (NAFLD).

METHODS

In the case-control study, 15 patients with SS, 16 with NASH, and 24 controls were included. In the randomized controlled trial, NAFLD patients were assigned to vitamin E (400 IU/d) or spironolactone (25 mg/d) plus vitamin E for 52 weeks.

RESULTS

Noggin levels were lower in SS (5.8 ± 1.5 pmol/l) and NASH (8.7 ± 2.4 pmol/l) patients than in controls (13.7 ± 2.7 pmol/l; p for trend = 0.040), but were similar in SS and NASH patients. After adjustment for potential cofounders, log(noggin) remained different between groups. Log(noggin) levels similarly increased post-treatment in both groups: log(noggin) was not different between groups (p = 0.20), but increased within groups over time (p < 0.001), without a significant group × time interaction (p = 0.62). Log(noggin) significantly increased at month 2 post-treatment (p = 0.008 vs. baseline) and remained stable thereafter.

CONCLUSIONS

Lower noggin levels were observed in NAFLD patients than in controls. Noggin levels increased similarly by either combined low-dose spironolactone plus vitamin E or vitamin E monotherapy.

TRIAL REGISTRATION

NCT01147523.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine

UniBE Contributor:

Doulberis, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2520-8721

Publisher:

Springer

Language:

English

Submitter:

Tobias Tritschler

Date Deposited:

07 Feb 2019 10:59

Last Modified:

05 Dec 2022 15:24

Publisher DOI:

10.1007/s42000-018-0083-8

PubMed ID:

30467685

Uncontrolled Keywords:

Bone morphogenetic protein Noggin Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Oxidative stress Simple steatosis

BORIS DOI:

10.7892/boris.123190

URI:

https://boris.unibe.ch/id/eprint/123190

Actions (login required)

Edit item Edit item
Provide Feedback