Noggin levels in nonalcoholic fatty liver disease: the effect of vitamin E treatment.

Polyzos, Stergios A; Kountouras, Jannis; Anastasilakis, Athanasios D; Makras, Polyzois; Hawa, Gerhard; Sonnleitner, Linda; Missbichler, Albert; Doulberis, Michael; Katsinelos, Panagiotis; Terpos, Evangelos (2018). Noggin levels in nonalcoholic fatty liver disease: the effect of vitamin E treatment. Hormones, 17(4), pp. 573-579. Springer 10.1007/s42000-018-0083-8

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AIM The evaluation of (a) noggin levels in patients with simple steatosis (SS) vs. nonalcoholic steatohepatitis (NASH) vs. controls, and (b) the effect of combined spironolactone plus vitamin E vs. vitamin E monotherapy on noggin levels in biopsy-proven patients with nonalcoholic fatty liver disease (NAFLD). METHODS In the case-control study, 15 patients with SS, 16 with NASH, and 24 controls were included. In the randomized controlled trial, NAFLD patients were assigned to vitamin E (400 IU/d) or spironolactone (25 mg/d) plus vitamin E for 52 weeks. RESULTS Noggin levels were lower in SS (5.8 ± 1.5 pmol/l) and NASH (8.7 ± 2.4 pmol/l) patients than in controls (13.7 ± 2.7 pmol/l; p for trend = 0.040), but were similar in SS and NASH patients. After adjustment for potential cofounders, log(noggin) remained different between groups. Log(noggin) levels similarly increased post-treatment in both groups: log(noggin) was not different between groups (p = 0.20), but increased within groups over time (p < 0.001), without a significant group × time interaction (p = 0.62). Log(noggin) significantly increased at month 2 post-treatment (p = 0.008 vs. baseline) and remained stable thereafter. CONCLUSIONS Lower noggin levels were observed in NAFLD patients than in controls. Noggin levels increased similarly by either combined low-dose spironolactone plus vitamin E or vitamin E monotherapy. TRIAL REGISTRATION NCT01147523.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine

UniBE Contributor:

Doulberis, Michael


600 Technology > 610 Medicine & health








Christine Baumgartner

Date Deposited:

07 Feb 2019 10:59

Last Modified:

04 Dec 2019 22:46

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Bone morphogenetic protein Noggin Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Oxidative stress Simple steatosis




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