Percutaneous patent foramen ovale closure during live case demonstrations.

Praz, Fabien; Siontis, Georgios; Xhigoli, Adrian; Wahl, Andreas; Susuri, Njomeza; Stortecky, Stefan; Moschovitis, Aris; Räber, Lorenz; Pilgrim, Thomas; Windecker, Stephan; Meier, Bernhard (2019). Percutaneous patent foramen ovale closure during live case demonstrations. Catheterization and cardiovascular interventions, 93(5), pp. 982-988. Wiley-Blackwell 10.1002/ccd.28018

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Live case demonstrations serve as an educational tool for interventional techniques in cardiology. The aim of this study was to assess the safety and technical success of percutaneous patent foramen ovale (PFO) closure during live case demonstrations.


All patients who had undergone percutaneous PFO closure with Amplatzer devices during live case demonstrations at our institution were consecutively included in this retrospective analysis. Procedure related events were compared with summary event rates derived from the eight randomized controlled trials (RCTs) investigating PFO closure, as well as with a propensity matched cohort of patients treated under usual conditions.


From April 2004 to June 2015, 142 patients underwent percutaneous PFO closure during live demonstrations, mainly for secondary prevention of cryptogenic cerebrovascular events. The interventions were fluoroscopy guided and successful in all but three cases (2%). Minor adverse events occurred in nine patients (6%). Contrast TEE performed at about 6 months showed complete closure in 84%. No significant differences with regard to technical success and major complications rate were found compared to RCTs, except for an increased rate of minor bleeding observed during live case demonstrations (P for difference < 0.001), mainly attributable to concomitant arterial access for incidental coronary angiography performed in 70% of patients. Except for slightly longer procedure duration, no difference was found compared to a matched population treated under usual conditions.


Percutaneous PFO closure can be performed during live case demonstrations with the same high technical success as during routine cases.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Praz, Fabien Daniel, Siontis, Georgios, Wahl, Andreas, Susuri, Njomeza (A), Stortecky, Stefan, Moschovitis, Aris, Räber, Lorenz, Pilgrim, Thomas, Windecker, Stephan, Meier, Bernhard


600 Technology > 610 Medicine & health








Tobias Tritschler

Date Deposited:

05 Feb 2019 14:54

Last Modified:

29 Mar 2023 23:36

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

PFO closure cryptogenic stroke live case patent foramen ovale




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