Neutrophils mitigate the systemic host response during endotoxemia in mice.

van der Meer, Anne Jan; Ding, Chao; Hoogendijk, Arie Johan; de Vos, Alex F; Boon, Louis; Zeerleder, Sacha S.; van der Poll, Tom (2019). Neutrophils mitigate the systemic host response during endotoxemia in mice. Immunology, 156(3), pp. 277-281. Wiley-Blackwell 10.1111/imm.13026

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Recent studies have suggested that neutrophils can exert anti-inflammatory effects. To determine the role of neutrophils in the acute response to lipopolysaccharide (LPS), a component of the Gram-negative bacterial cell wall, we challenged neutrophil-depleted and control mice with LPS and analyzed the plasma concentrations of biomarkers indicative of the cytokine and chemokine network, activation of coagulation and the vascular endothelium, and cellular injury. We here show that neutrophils serve an anti-inflammatory role upon LPS administration, as reflected by sustained elevations of multiple cytokines and chemokines, and enhanced release of nucleosomes in mice depleted of neutrophils, compared with control mice.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory

UniBE Contributor:

Zeerleder, Sacha Sergio

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0019-2805

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Pierrette Durand Lüthi

Date Deposited:

08 Jan 2019 13:42

Last Modified:

25 Oct 2019 02:56

Publisher DOI:

10.1111/imm.13026

PubMed ID:

30472736

Uncontrolled Keywords:

chemokines cytokines inflammation neutrophil

BORIS DOI:

10.7892/boris.123272

URI:

https://boris.unibe.ch/id/eprint/123272

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