Colon constipation in horses after sustained-release buprenorphine administration.

Levionnois, Olivier; Graubner, Claudia; Spadavecchia, Claudia (2018). Colon constipation in horses after sustained-release buprenorphine administration. Veterinary anaesthesia and analgesia, 45(6), pp. 876-880. Elsevier 10.1016/j.vaa.2018.08.004

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OBJECTIVE To investigate the pharmacological profile and side effects of buprenorphine administered as a sustained-release formulation in horses. STUDY DESIGN Pilot trial. ANIMALS A total of four experimental horses, aged 18-27 years and weighing 508-578 kg. METHODS Buprenorphine (0.1 mg kg) was mixed as a freshly prepared sterile solution with a sustained-release drug carrier. It was administered by the subcutaneous (n = 2) or intramuscular (n = 2) route. During the experiment, the horses were closely monitored, equipped with a step counter and blood samples were collected for quantification of buprenorphine in plasma. RESULTS All four horses developed colon constipation requiring medical therapy, together with increased locomotor activity. One horse, requiring surgical treatment of colon constipation, was euthanized during recovery from anaesthesia for weakness and severe lower airway obstruction. The three other horses recovered fully within 5-7 days. Plasma buprenorphine concentrations were between 1 and 8 ng mL for approximately 48 hours. No local reaction was observed at the injection sites. CONCLUSIONS AND CLINICAL RELEVANCE Administration of the sustained-release formulation of buprenorphine at a dose of 0.1 mg kg resulted in plasma concentrations compatible with antinociceptive activity for at least 48 hours. The observed severe and undesirable effects of colon constipation and increased locomotor activity definitely preclude clinical use of sustained-release buprenorphine at this dose.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Equine Clinic
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Anaesthesiology

UniBE Contributor:

Levionnois, Olivier; Graubner, Claudia and Spadavecchia, Claudia

Subjects:

600 Technology > 630 Agriculture

ISSN:

1467-2987

Publisher:

Elsevier

Language:

English

Submitter:

Andrea Gassmann-Suter

Date Deposited:

17 Apr 2019 14:39

Last Modified:

23 Oct 2019 10:31

Publisher DOI:

10.1016/j.vaa.2018.08.004

PubMed ID:

30297131

Uncontrolled Keywords:

buprenorphine colic constipation gastrointestinal horse slow-release

BORIS DOI:

10.7892/boris.123281

URI:

https://boris.unibe.ch/id/eprint/123281

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