FAM83G/Fam83g genetic variants affect canine and murine hair formation.

Balmer, Pierre; Fellay, Auxanne K; Sayar, Beyza S; Hariton, William V J; Wiener, Dominique J; Galichet, Arnaud; Müller, Eliane Jasmine; Roosje, Petra J (2019). FAM83G/Fam83g genetic variants affect canine and murine hair formation. Experimental dermatology, 28(4), pp. 350-354. Blackwell 10.1111/exd.13729

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FAM83G/Fam83g genetic variants have been described in dogs, mice and recently also in humans. They are associated with palmoplantar keratoderma and altered hair or coat phenotype, reported as wooly phenotype in mice. FAM83G/Fam83g is an unexplored effector of temporally and spatially coordinated Wnt and BMP signalling which are key pathways in pre- and postnatal hair follicle morphogenesis and differentiation. The aim of this study was to unravel phenotypic consequences of FAM83G/Fam83g variants on hair coat formation in dogs and mice. Our results show differences in hair types and hair shaft structures in both species. Additionally, mice exhibit deregulated hair cycle progression which timely correlates with defective Wnt signalling (Axin2) and Bmp2/4 expression. These results affirm the involvement of FAM83G in hair morphogenesis, hair follicle differentiation and cycling.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Müller, Eliane Jasmine

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0906-6705

Publisher:

Blackwell

Language:

English

Submitter:

Sandra Nyffenegger

Date Deposited:

11 Feb 2019 14:48

Last Modified:

01 May 2019 01:31

Publisher DOI:

10.1111/exd.13729

PubMed ID:

29963719

Uncontrolled Keywords:

FAM83G dog hair mouse

BORIS DOI:

10.7892/boris.123358

URI:

https://boris.unibe.ch/id/eprint/123358

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