Thin Endometrium Is Also Associated With Lower Clinical Pregnancy Rate in Unstimulated Menstrual Cycles: A Study Based on Natural Cycle IVF.

von Wolff, Michael; Fäh, Monika; Roumet, Marie; Mitter, Vera; Stute, Petra; Griesinger, Georg; Kohl Schwartz, Alexandra (2018). Thin Endometrium Is Also Associated With Lower Clinical Pregnancy Rate in Unstimulated Menstrual Cycles: A Study Based on Natural Cycle IVF. Frontiers in endocrinology, 9, p. 776. Frontiers Research Foundation 10.3389/fendo.2018.00776

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Does the endometrial thickness (EMT) at the time of follicle aspiration correlate with the pregnancy rate in unstimulated menstrual cycles? This is a retrospective, observational single center study.105 women with regular menstrual cycles undergoing their first NC-IVF cycle with an embryo transfer were analyzed. Clinical pregnancy and live birth rates were calculated and data were adjusted for women's age, cycle day of follicle aspiration and body mass index (BMI). Age of participants was 35.0 y [32.0; 37.0]. Follicle aspiration was performed on day 14.0 [12.0; 15.0] of the cycle. Total clinical pregnancy rate was 24.8% and live birth rate 15.2% per transfer. Pregnancy rate in women with endometrial thickness ≤7 mm ( = 27) was 7.4 and 30.8% in women >7 mm ( = 78) (OR 5.56, 1.22-25.36) ( = 0.03). Live birth rates were not significantly different. Quadratic regression analysis revealed lower pregnancy rates in women with thin (around <8 mm) as well as with thick (around >11 mm) endometria. -value after crude quadratic analysis was 0.028 and after adjustment for age, day of aspiration and BMI was 0.039. Significance was not reached for live birth rates. Thin endometrium should also be considered as an independent negative prognostic factor for achieving pregnancy in women without ovarian stimulation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology
04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern

UniBE Contributor:

von Wolff, Michael; Fäh, Monika; Roumet, Marie Camille; Mitter, Vera Ruth; Stute, Petra and Kohl Schwartz, Alexandra

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1664-2392

Publisher:

Frontiers Research Foundation

Language:

English

Submitter:

Tanya Karrer

Date Deposited:

17 Jan 2019 13:35

Last Modified:

05 Feb 2019 11:07

Publisher DOI:

10.3389/fendo.2018.00776

PubMed ID:

30619099

Uncontrolled Keywords:

endometrium live birth rate natural cycle IVF pregnancy rate spontaneous cylce

BORIS DOI:

10.7892/boris.123523

URI:

https://boris.unibe.ch/id/eprint/123523

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