Rodent malaria models: insights into human disease and parasite biology.

De Niz, Mariana; Heussler, Volker (2018). Rodent malaria models: insights into human disease and parasite biology. Current opinion in microbiology, 46, pp. 93-101. Elsevier 10.1016/j.mib.2018.09.003

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The use of rodents as model organisms to study human disease is based on the genetic and physiological similarities between the species. Successful molecular methods to generate transgenic reporter or humanized rodents has rendered rodents as powerful tools for understanding biological processes and host-pathogen interactions relevant to humans. In malaria research, rodent models have been pivotal for the study of liver stages, syndromes arising from blood stages of infection, and malaria transmission to and from the mammalian host. Importantly, many in vivo findings are comparable to pathology observed in humans only when adequate combinations of rodent strains and Plasmodium parasites are used.

Item Type:

Journal Article (Review Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology > Malaria
08 Faculty of Science > Department of Biology > Institute of Cell Biology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Heussler, Volker

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

1879-0364

Publisher:

Elsevier

Funders:

[42] Schweizerischer Nationalfonds

Language:

English

Submitter:

Prof Volker Heussler

Date Deposited:

11 Feb 2019 10:35

Last Modified:

11 Feb 2019 10:35

Publisher DOI:

10.1016/j.mib.2018.09.003

PubMed ID:

30317152

BORIS DOI:

10.7892/boris.123527

URI:

https://boris.unibe.ch/id/eprint/123527

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