Caprine PRNP polymorphisms at codons 171, 211, 222 and 240 in a Greek herd and their association with classical scrapie

Bouzalas I. G., I.G.; Dovas C. I., C.I.; Banos G., G.; Papanastasopoulou M., M.; Kritas S., S.; Oevermann A., A.; Papakostaki D., D.; Evangelia C., C.; Papadopoulos O., O.; Seuberlich T., T.; Koptopoulos G., G. (2010). Caprine PRNP polymorphisms at codons 171, 211, 222 and 240 in a Greek herd and their association with classical scrapie. Journal of general virology, 91(Pt 6), pp. 1629-34. Reading: Society for General Microbiology 10.1099/vir.0.017350-0

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The association between PRNP variation and scrapie incidence was investigated in a highly affected Greek goat herd. Four mutations were identified at codons 171Q/R, 211R/Q, 222Q/K and 240P/S. Lysine at codon 222 was found to be associated with the protection from natural scrapie (P=0.0111). Glutamine at codon 211 was observed in eight animals, all of them being scrapie-negative, indicating a possible protective role of this polymorphism although statistical analysis failed to support it (P=0.1074). A positive association (P=0.0457) between scrapie-affected goats and the wild-type Q(171)R(211)Q(222)S(240) allele is presented for the first time. In addition, a novel R(171)RQS allele, which is identical to the A(136)R(154)R(171) allele that has been associated with resistance to classical scrapie in sheep, was observed in low frequency. Resistant alleles that include K(222) and Q(211) are absent or rare in sheep and can provide the basis for the development of a feasible breeding programme for scrapie eradication in goats.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research

UniBE Contributor:

Oevermann, Anna and Seuberlich, Torsten

ISSN:

0022-1317

Publisher:

Society for General Microbiology

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:32

Last Modified:

21 Jan 2014 15:05

Publisher DOI:

10.1099/vir.0.017350-0

Web of Science ID:

000278702400026

URI:

https://boris.unibe.ch/id/eprint/12363 (FactScience: 218695)

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