Polyzos, Stergios A; Kountouras, Jannis; Mavrouli, Maria; Katsinelos, Panagiotis; Doulberis, Michael; Gavana, Elpida; Duntas, Leonidas (2019). Selenoprotein P in Patients with Nonalcoholic Fatty Liver Disease. Experimental and clinical endocrinology & diabetes, 127(9), pp. 598-602. Thieme 10.1055/a-0811-9136
![[img]](https://boris.unibe.ch/style/images/fileicons/text.png) |
Text
Stergios, Exp Clin Endocrinol Diabetes 2019.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (267kB) | Request a copy |
OBJECTIVE
Main aim of this study was to evaluate circulating selenoprotein P (SEPP) levels in patients with simple steatosis (SS) and nonalcoholic steatohepatitis (NASH) compared with healthy controls.
METHODS
Thirty-one patients with biopsy-proven NAFLD (15 with SS, 10 with borderline NASH, 6 with definite NASH) and 27 matched controls without NAFLD were enrolled. Serum SEPP levels and liver function tests plus biochemical parameters were measured with ELISA and standard methods, respectively. Homeostatic model of assessment - insulin resistance (HOMA-IR) was calculated.
RESULTS
SEPP levels were statistically different between groups (p-value for trend=0.043). In pairwise comparisons, SEPP was lower in definite NASH compared with controls (p=0.029), but not SS (p=0.18) or borderline NASH (p=0.35). SEPP was not different between controls, SS and borderline NASH. The unadjusted trend between the controls, SS and NASH patients remained essentially unchanged after adjustment for age, sex, log(ALT) and waist circumference, but it marginally lost significance when log(HOMA-IR) entered into the model. SEPP levels were not different between groups of different severity of steatosis, fibrosis, hepatocellular ballooning, lobular and portal inflammation.
CONCLUSIONS
Lower SEPP levels were observed in patients with definite NASH compared with controls, a finding warranting larger studies.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine |
UniBE Contributor: |
Doulberis, Michael |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0947-7349 |
Publisher: |
Thieme |
Language: |
English |
Submitter: |
Tobias Tritschler |
Date Deposited: |
05 Feb 2019 12:28 |
Last Modified: |
05 Dec 2022 15:24 |
Publisher DOI: |
10.1055/a-0811-9136 |
PubMed ID: |
30625508 |
BORIS DOI: |
10.7892/boris.123656 |
URI: |
https://boris.unibe.ch/id/eprint/123656 |
Actions (login required)
 |
Edit item |