Retrospective study of salinomycin toxicosis in 66 cats

Pakozdy, Akos; Challande-Kathman, Iris; Doherr, Marcus; Cizinauskas, Sigitas; Wheeler, Simon J.; Oevermann, Anna; Jaggy, Andre (2010). Retrospective study of salinomycin toxicosis in 66 cats. Veterinary medicine international, 2010, pp. 1-5. Cairo (Egypt): SAGE-Hindawi 10.4061/2010/147142

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We examined 66 cats with salinomycin intoxication. Salinomycin caused different LMN signs of varying degrees of severity in all cases. Changes in blood work were unspecific, with the most frequent being increased serum creatine kinase activity, leukocytosis, and increased liver enzymes. Pathological electrodiagnostic findings: fibrillation potentials and positive sharp waves were detected in 10 cases, motor nerve conductance velocity was mildly decreased in 8/12 cats, and sensory nerve conductance velocity and repetitive nerve stimulation were normal in all examined cases. In five cases the peripheral neuropathy was confirmed by pathohistology. Fluid therapy and supportive care were used as therapy and 52 cats recovered completely. The probability for complete remission was significantly different between mildly and severely affected cases. It seems that the severity of clinical signs and prognosis correlate well with the amount of toxin ingested. We conclude that early recognition and decontamination combined with supportive care results in complete recovery.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DVK - Clinical Research (discontinued)
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research

UniBE Contributor:

Doherr, Marcus and Oevermann, Anna

ISSN:

2090-8113

Publisher:

SAGE-Hindawi

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:32

Last Modified:

08 Jun 2016 10:29

Publisher DOI:

10.4061/2010/147142

BORIS DOI:

10.7892/boris.12367

URI:

https://boris.unibe.ch/id/eprint/12367 (FactScience: 218699)

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