Absolute Values of Optical Properties (μa, μ's, μeff and DPF) of Human Head Tissue: Dependence on Head Region and Individual.

Scholkmann, Felix; Zohdi, Hamoon; Nasseri, Nassim; Wolf, Ursula (2018). Absolute Values of Optical Properties (μa, μ's, μeff and DPF) of Human Head Tissue: Dependence on Head Region and Individual. Advances in experimental medicine and biology, 1072, pp. 325-330. Springer 10.1007/978-3-319-91287-5_52

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BACKGROUND Absolute optical properties (i.e., the absorption coefficient, μa, and the reduced scattering coefficient, μ's) of head tissue can be measured with frequency-domain near-infrared spectroscopy (FD-NIRS). AIM We investigated how the absolute optical properties depend on the individual subject and the head region. MATERIALS AND METHODS The data set used for the analysis comprised 31 single FD-NIRS measurements of 14 healthy subjects (9 men, 5 women, aged 33.4 ± 10.5 years). From an 8-min measurement (resting-state; FD-NIRS device: Imagent, ISS Inc.; bilateral over the prefrontal cortex, PFC, and visual cortex, VC) median values were calculated for μa and μ's as well as the effective attenuation coefficient (μeff) and the differential pathlength factor (DPF). The measurement was done for each subject one to three times with at least 24 h between the measurements. RESULTS (i) A Bayesian ANOVA analysis revealed that head region and subject were the most significant main effects on μa, μ's and μeff, as well as DPF, respectively. (ii) At the VC, μa, μ's and μeff had higher values compared to the PFC. (iii) The differences in the optical properties between PFC and VC were age-dependent. (iv) All optical properties also were age-dependent. This was strongest for the properties of the PFC compared to the VC. DISCUSSION AND CONCLUSION Our analysis demonstrates that all optical head tissue properties (μa, μ's, μeff and DPF) were dependent on the head region, individual subject and age. The optical properties of the head are like a 'fingerprint' for the individual subject. Assuming constant optical properties for the whole head should be carefully reconsidered.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Medical Education > Institute of Complementary and Integrative Medicine (IKIM)

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Scholkmann, Felix; Zohdi, Hamoon; Nasseri, Nassim and Wolf, Ursula


500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health








Hamoon Zohdi

Date Deposited:

21 Jan 2019 15:02

Last Modified:

16 Dec 2019 20:16

Publisher DOI:


PubMed ID:






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