van den Hoogen, Christel; van der Horst, Geertje; Cheung, Henry; Buijs, Jeroen T; Lippitt, Jenny M; Guzmán-Ramírez, Natalia; Hamdy, Freddie C; Eaton, Colby L; Thalmann, George N; Cecchini, Marco G; Pelger, Rob C M; van der Pluijm, Gabri (2010). High aldehyde dehydrogenase activity identifies tumor-initiating and metastasis-initiating cells in human prostate cancer. Cancer research, 70(12), pp. 5163-73. Birmingham, Ala.: American Association for Cancer Research AACR 10.1158/0008-5472.CAN-09-3806
Full text not available from this repository.Metastatic progression of advanced prostate cancer is a major clinical problem. Identifying the cell(s) of origin in prostate cancer and its distant metastases may permit the development of more effective treatment and preventive therapies. In this study, aldehyde dehydrogenase (ALDH) activity was used as a basis to isolate and compare subpopulations of primary human prostate cancer cells and cell lines. ALDH-high prostate cancer cells displayed strongly elevated clonogenicity and migratory behavior in vitro. More strikingly, ALDH-high cells readily formed distant metastases with strongly enhanced tumor progression at both orthotopic and metastatic sites in preclinical models. Several ALDH isoforms were expressed in human prostate cancer cells and clinical specimens of primary prostate tumors with matched bone metastases. Our findings suggest that ALDH-based viable cell sorting can be used to identify and characterize tumor-initiating and, more importantly perhaps, metastasis-initiating cells in human prostate cancer.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology |
UniBE Contributor: |
Thalmann, George, Cecchini, Marco Giovanni |
ISSN: |
0008-5472 |
Publisher: |
American Association for Cancer Research AACR |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:10 |
Last Modified: |
05 Dec 2022 14:00 |
Publisher DOI: |
10.1158/0008-5472.CAN-09-3806 |
PubMed ID: |
20516116 |
Web of Science ID: |
000278749600039 |
URI: |
https://boris.unibe.ch/id/eprint/1238 (FactScience: 202390) |
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