Zipperle, Ljerka; Langedijk, J.P.; Orvell, C.; Vandevelde, Marc; Zurbriggen, Andreas; Plattet, Philippe (2010). Identification of key residues in virulent canine distemper virus hemagglutinin that control CD150/SLAM-binding activity. Journal of virology, 84(18), pp. 9618-24. Baltimore: American Society for Microbiology 10.1128/JVI.01077-10
Full text not available from this repository.Morbillivirus cell entry is controlled by hemagglutinin (H), an envelope-anchored viral glycoprotein determining interaction with multiple host cell surface receptors. Subsequent to virus-receptor attachment, H is thought to transduce a signal triggering the viral fusion glycoprotein, which in turn drives virus-cell fusion activity. Cell entry through the universal morbillivirus receptor CD150/SLAM was reported to depend on two nearby microdomains located within the hemagglutinin. Here, we provide evidence that three key residues in the virulent canine distemper virus A75/17 H protein (Y525, D526, and R529), clustering at the rim of a large recessed groove created by beta-propeller blades 4 and 5, control SLAM-binding activity without drastically modulating protein surface expression or SLAM-independent F triggering.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Neurology |
UniBE Contributor: |
Zipperle, Ljerka, Vandevelde, Marc, Zurbriggen, Andreas (A), Plattet, Philippe |
ISSN: |
0022-538X |
Publisher: |
American Society for Microbiology |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:32 |
Last Modified: |
29 Mar 2023 23:32 |
Publisher DOI: |
10.1128/JVI.01077-10 |
Web of Science ID: |
000281110500061 |
URI: |
https://boris.unibe.ch/id/eprint/12389 (FactScience: 218723) |
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