Imaging Pediatric Multiple Sclerosis-Challenges and Recent Advances.

Parmar, Katrin; Banwell, Brenda L; Akbar, Nadine; Bigi, Sandra (2018). Imaging Pediatric Multiple Sclerosis-Challenges and Recent Advances. Neuropediatrics, 49(3), pp. 165-172. Thieme 10.1055/s-0038-1635123

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Pediatric onset multiple sclerosis (POMS) is a rare disease with an incidence of 0.07 to 2.9/100'000 children per year. It follows a relapsing-remitting disease course and is characterized by rapid accrual of inflammatory lesions, high relapse frequency, and early cognitive impairment. Magnetic resonance imaging (MRI) plays a pivotal role in the diagnosis of POMS, and in the exclusion of other disorders mimicking POMS. Furthermore, MRI aids in disease monitoring, and in the evaluation of therapeutic efficacy in both clinical practice and clinical trials. Volumetric MRI studies, diffusion tensor imaging, resting-state, and task-based functional MRI provide deeper insight into the impact of POMS on maturing neural networks. This review article aims to highlight the importance of MRI in the care of POMS patients and to provide an overview on the different MRI techniques used in the management of POMS.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Bigi, Sandra

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0174-304X

Publisher:

Thieme

Language:

English

Submitter:

Karen Lidzba

Date Deposited:

20 Feb 2019 17:04

Last Modified:

04 Dec 2019 19:15

Publisher DOI:

10.1055/s-0038-1635123

PubMed ID:

29482255

BORIS DOI:

10.7892/boris.123922

URI:

https://boris.unibe.ch/id/eprint/123922

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