Comparison of three block bone substitutes for bone regeneration: long-term observation in the beagle dog.

Sawada, Kosaku; Nakahara, Ken; Haga-Tsujimura, Maiko; Iizuka, Tateyuki; Kobayashi, Masako; Igarashi, Kensuke; Saulacic, Nikola (2018). Comparison of three block bone substitutes for bone regeneration: long-term observation in the beagle dog. Odontology, 106(4), pp. 398-407. Springer 10.1007/s10266-018-0352-7

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This study aimed to evaluate the impact of three types of block bone substitute material on bone formation and graft resorption in vivo. Standardized bone defects (n = 4 defects/animal) were created in the calvaria of nine dogs. Block bone substitutes made of deproteinized bovine bone mineral (DBBM), beta-tricalcium phosphate (β-TCP) and a mixture alpha-TCP and hydroxyapatite (α-TCP/HA) were inserted into the bone defects. A fourth defect was left untreated (empty). All sites were covered with a collagenous membrane. Block biopsies were harvested at 3, 6 and 12 months post-implantation and analyzed by micro-CT and histology. Biomaterial absorption was minimal and incorporation within the defect margin was good for all biomaterials. However, β-TCP demonstrated a relatively greater volume of new bone formation and less residual material volume when compared with DBBM and α-TCP/HA. Conversely, α-TCP/HA showed higher osteoconductive potential and a greater new bone area compared with the other two biomaterials. The block bone substitutes used in the present in vivo study showed advantageous in terms of maintenance of their original form in bony defect. However, the positive impact of all biomaterials on new bone formation and replacement of bone was minor even at 12 months. These findings indicate that block bone substitutes are not well suited to vertical bone augmentation. Further investigations are required to improve the insufficient new bone volume for promising clinical results.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Schädel-, Kiefer- und Gesichtschirurgie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Schädel-, Kiefer- und Gesichtschirurgie

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Craniomaxillofacial Surgery
04 Faculty of Medicine > School of Dental Medicine

UniBE Contributor:

Sawada, Kosaku; Nakahara, Ken; Haga-Tsujimura, Maiko; Iizuka, Tateyuki; Kobayashi, Masako; Igarashi, Kensuke and Saulacic, Nikola

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1618-1255

Publisher:

Springer

Language:

English

Submitter:

Caroline Dominique Zürcher

Date Deposited:

07 Mar 2019 15:36

Last Modified:

07 Mar 2019 15:36

Publisher DOI:

10.1007/s10266-018-0352-7

PubMed ID:

29557992

Uncontrolled Keywords:

Alpha-tricalcium phosphate Beta-tricalcium phosphate Block bone substitutes Canine calvaria Deproteinized bovine bone mineral

BORIS DOI:

10.7892/boris.123926

URI:

https://boris.unibe.ch/id/eprint/123926

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