Fabrication and evaluation of carbonate apatite-coated calcium carbonate bone substitutes for bone tissue engineering.

Kobayashi, Masako; Tsuru, Kanji; Nagai, Hirokazu; Fujisawa, Kenji; Kudoh, Takaharu; Ohe, Go; Ishikawa, Kunio; Miyamoto, Youji (2018). Fabrication and evaluation of carbonate apatite-coated calcium carbonate bone substitutes for bone tissue engineering. Journal of tissue engineering and regenerative medicine, 12(10), pp. 2077-2087. John Wiley & Sons 10.1002/term.2742

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Carbonate apatite-coated calcium carbonate (CO Ap/CaCO ) was fabricated through a dissolution-precipitation reaction using CaCO granules as a precursor to accelerate bone replacement based on superior osteoconductivity of the CO Ap shell, along with Ca release from the CaCO core and quicker resorption of the CaCO core. In the present study, CaCO , 10% CO Ap/CaCO , 30% CO Ap/CaCO , and CO Ap granules were fabricated and examined histologically to evaluate their potential as bone substitutes. Larger contents of CaCO in the granules resulted in higher Ca release and promoted cell proliferation of murine preosteoblasts at 6 days compared with CO Ap. Interestingly, in a rabbit femur defect model, 10% CO Ap/CaCO induced significantly higher new bone formation and higher material resorption compared with CO Ap at 8 weeks. Nevertheless, CO Ap showed a superior osteoconductive potential compared with 10% CO Ap/CaCO at 8 weeks. All tested granules were most likely resorbed by cell mediation including multinucleated giant cell functions. Therefore, we conclude that CO Ap/CaCO has a positive potential for bone tissue engineering based on well-controlled calcium release, bone formation, and material resorption.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Schädel-, Kiefer- und Gesichtschirurgie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Schädel-, Kiefer- und Gesichtschirurgie

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Craniomaxillofacial Surgery

UniBE Contributor:

Kobayashi, Masako (B)

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1932-6254

Publisher:

John Wiley & Sons

Language:

English

Submitter:

Caroline Dominique Zürcher

Date Deposited:

21 Feb 2019 15:30

Last Modified:

29 Mar 2023 23:36

Publisher DOI:

10.1002/term.2742

PubMed ID:

30058260

Uncontrolled Keywords:

bone regeneration bone substitute bone tissue engineering calcium carbonate carbonate apatite osteoconductivity

BORIS DOI:

10.7892/boris.123958

URI:

https://boris.unibe.ch/id/eprint/123958

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