Bohlmann, Michael K; Luedders, Doerte W; Strowitzki, Thomas; von Wolff, Michael (2010). Specific secretory phase endometrial leukocytes of women with two and more consecutive idiopathic abortions are not significantly different from healthy controls. Archives of gynecology and obstetrics, 281(6), pp. 983-90. Berlin: Springer 10.1007/s00404-009-1179-9
|
Text
Bohlmann2010_Article_SpecificSecretoryPhaseEndometr.pdf - Published Version Available under License Publisher holds Copyright. Download (567kB) | Preview |
OBJECTIVE: To analyze concentrations of endometrial leukocytes in patients with idiopathic-repeated abortions. MATERIALS AND METHODS: Biopsies of exactly dated secretory endometrium in 25 patients with idiopathic-repeated abortions and 10 control patients without a history of miscarriage were compared with respect to the concentrations of T-helper cells (CD4), cytotoxic T-cells (CD8), B-cells (CD19) and uterine natural killer cells (CD56) by immunohistochemistry and RNase protection assays. RESULTS: All examined cells were detectable within secretory endometrium. No statistically significant differences of the examined immune-cell concentrations were seen between the control group and the repeated miscarriage group by either test. CONCLUSION: This study suggests that the concentrations of specific endometrial leukocytes in a non-pregnant cycle are not associated with repeated pregnancy loss. Thus, the hypothesis of an altered endometrial immunity in patients with repeated miscarriages, symbolized by persistently differing local immune-cell concentrations, has to be questioned.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology |
UniBE Contributor: |
von Wolff, Michael |
ISSN: |
0932-0067 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:07 |
Last Modified: |
05 Dec 2022 14:00 |
Publisher DOI: |
10.1007/s00404-009-1179-9 |
PubMed ID: |
19847451 |
Web of Science ID: |
000277282700002 |
BORIS DOI: |
10.48350/124 |
URI: |
https://boris.unibe.ch/id/eprint/124 (FactScience: 196234) |
Actions (login required)
 |
Edit item |